PT  - JOURNAL ARTICLE
AU  - Atasoy, Mustafa
AU  - Pirim, Ibrahim
AU  - Bayrak, Omer F.
AU  - Ozdemir, Sevki
AU  - Ikbal, Mevlit
AU  - Erdem, Teoman
AU  - Aktas, Akin
TI  - Association of HLA class I and class II alleles with psoriasis vulgaris in Turkish population. Influence of type I and II psoriasis
DP  - 2006 Mar 01
TA  - Saudi Medical Journal
PG  - 373--376
VI  - 27
IP  - 3
4099  - http://smj.org.sa/content/27/3/373.short
4100  - http://smj.org.sa/content/27/3/373.full
SO  - Saudi Med J2006 Mar 01; 27
AB  - OBJECTIVE: To investigate the role of human leukocyte antigen (HLA) in susceptibility to psoriasis vulgaris in the Northeast region of Turkey and to contribute to the data related to HLA and psoriasis.METHODS: The study included 72 unrelated psoriatic patients (43 men and 29 women; aged 11-76 years) admitted to the Dermatology Department, University Research Hospital, Erzurum, Turkey between April 2002 and November 2003. We studied the distribution of HLA class I and II antigens in patients with psoriasis: 72 patients were divided into 2 groups according to the onset of psoriasis before age 40 years with family history (type I) and onset after age 40 without family history (type II). The HLA class I and II antigens were analyzed using the PCR-SSP method in 72 patients and in 104 controls.RESULTS: We found an increase in HLA-A*30 and A*68, B*7, B*13, B*57, Cw6, and DRB1*07 antigens in psoriatic patients compared with controls. As we compared type I and type II psoriasis with control group, B*57, Cw6 and DRB1*07 alleles were more significant in patients with type I psoriasis. Our patients with type II psoriasis represented a significant association with the HLA-B*13.CONCLUSION: Our findings along with previous HLA studies on psoriasis vulgaris patients from different racial groups showed that HLA-B*57 and DRB1*07 alleles are associated with the disease.