PT  - JOURNAL ARTICLE
AU  - Ercan, Önder
AU  - Köstü, Bülent
AU  - Bakacak, Murat
AU  - Aytaç-Tohma, Yusuf
AU  - Çoşkun, Bora
AU  - Avcı, Fazıl
AU  - Efe, Erkan
TI  - Comparison of solifenacin and fesoterodine in treatment of overactive bladder
AID  - 10.15537/smj.2015.10.12016
DP  - 2015 Oct 01
TA  - Saudi Medical Journal
PG  - 1181--1185
VI  - 36
IP  - 10
4099  - http://smj.org.sa/content/36/10/1181.short
4100  - http://smj.org.sa/content/36/10/1181.full
SO  - Saudi Med J2015 Oct 01; 36
AB  - Objectives: To compare the use of solifenacin and fesoterodine in treatment of overactive bladder (OAB).Methods: This prospective study was conducted on patients diagnosed with OAB who presenting to the Department of Obstetrics and Gynecology and Urology, School of Medicine, Kahramanmaraş Sütçü İmam University, Kahramanmaraş, Turkey between October 2013 and August 2014. Patients were randomized into 2 groups. Group 1 (n=60) received 5 mg solifenacin per day, while Group 2 (n=59) received 4 mg fesoterodine per day. All the patients’ OAB symptom scores (OABSS) in weeks 0, 4, and 12 were recorded. In addition, treatment costs and side effects of the drugs were evaluated.Results: Average OABSS (score 1) was determined as: 9.5 ± 2.8 for Group 1 and 10.7 ± 1.8 for Group 2 at week 0; 2.2 ± 1.2 (Group 1) and 2.4 ± 1.3 (Group 2) at week 4 (score 2); and 1.3 ± 0.5 for Group 1 and 1.3 ± 0.6 for Group 2 at week 12 (score 3). In addition, no statistically significant difference was found between the scores (p=0.062 (score 1), p=0.464 (score 2), and p=0.527 (score 3). The discontinuation rate of medication due to its side effects was 0 (0%) for Group 1, and 6 (10.2%) for Group 2. Intragroup changes in the scores 1-2, 1-3, and 2-3 values was statistically significant in both groups (p<0.001).Conclusion: No significant difference was found between the OABSS of these 2 drugs. However, discontinuation of drugs due to side effects was more frequent in fesoterodine.