RT Journal Article
SR Electronic
T1 Comparison of solifenacin and fesoterodine in treatment of overactive bladder
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 1181
OP 1185
DO 10.15537/smj.2015.10.12016
VO 36
IS 10
A1 Önder Ercan
A1 Bülent Köstü
A1 Murat Bakacak
A1 Yusuf Aytaç-Tohma
A1 Bora Çoşkun
A1 Fazıl Avcı
A1 Erkan Efe
YR 2015
UL http://smj.org.sa/content/36/10/1181.abstract
AB Objectives: To compare the use of solifenacin and fesoterodine in treatment of overactive bladder (OAB).Methods: This prospective study was conducted on patients diagnosed with OAB who presenting to the Department of Obstetrics and Gynecology and Urology, School of Medicine, Kahramanmaraş Sütçü İmam University, Kahramanmaraş, Turkey between October 2013 and August 2014. Patients were randomized into 2 groups. Group 1 (n=60) received 5 mg solifenacin per day, while Group 2 (n=59) received 4 mg fesoterodine per day. All the patients’ OAB symptom scores (OABSS) in weeks 0, 4, and 12 were recorded. In addition, treatment costs and side effects of the drugs were evaluated.Results: Average OABSS (score 1) was determined as: 9.5 ± 2.8 for Group 1 and 10.7 ± 1.8 for Group 2 at week 0; 2.2 ± 1.2 (Group 1) and 2.4 ± 1.3 (Group 2) at week 4 (score 2); and 1.3 ± 0.5 for Group 1 and 1.3 ± 0.6 for Group 2 at week 12 (score 3). In addition, no statistically significant difference was found between the scores (p=0.062 (score 1), p=0.464 (score 2), and p=0.527 (score 3). The discontinuation rate of medication due to its side effects was 0 (0%) for Group 1, and 6 (10.2%) for Group 2. Intragroup changes in the scores 1-2, 1-3, and 2-3 values was statistically significant in both groups (p<0.001).Conclusion: No significant difference was found between the OABSS of these 2 drugs. However, discontinuation of drugs due to side effects was more frequent in fesoterodine.