PT  - JOURNAL ARTICLE
AU  - Wang, Hui-Bo
AU  - Yang, Jun
TI  - The role of renin-angiotensin aldosterone system related micro-ribonucleic acids in hypertension
AID  - 10.15537/smj.2015.10.12458
DP  - 2015 Oct 01
TA  - Saudi Medical Journal
PG  - 1151--1155
VI  - 36
IP  - 10
4099  - http://smj.org.sa/content/36/10/1151.short
4100  - http://smj.org.sa/content/36/10/1151.full
SO  - Saudi Med J2015 Oct 01; 36
AB  - Micro-ribonucleic acids (miRNAs) are small (21-25 nucleotide) single-stranded, evolutionarily conserved non-protein-coding RNAs, which control diverse cellular functions by interacting with the 3’ untranslated region of specific target messenger RNAs at the post-transcriptional level. Research shows that an aberrant expression profile of miRNAs has been linked to a series of diseases, including hypertension. In the past few decades, it has been demonstrated that excessive activation of the renin-angiotensin aldosterone system (RAAS) involves in the pathogenesis of hypertension. This article reviews the latest insights in the identification of RAAS-correlative miRNAs and the potential mechanisms for their roles in hypertension.