RT Journal Article
SR Electronic
T1 The role of renin-angiotensin aldosterone system related micro-ribonucleic acids in hypertension
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 1151
OP 1155
DO 10.15537/smj.2015.10.12458
VO 36
IS 10
A1 Wang, Hui-Bo
A1 Yang, Jun
YR 2015
UL http://smj.org.sa/content/36/10/1151.abstract
AB Micro-ribonucleic acids (miRNAs) are small (21-25 nucleotide) single-stranded, evolutionarily conserved non-protein-coding RNAs, which control diverse cellular functions by interacting with the 3’ untranslated region of specific target messenger RNAs at the post-transcriptional level. Research shows that an aberrant expression profile of miRNAs has been linked to a series of diseases, including hypertension. In the past few decades, it has been demonstrated that excessive activation of the renin-angiotensin aldosterone system (RAAS) involves in the pathogenesis of hypertension. This article reviews the latest insights in the identification of RAAS-correlative miRNAs and the potential mechanisms for their roles in hypertension.