PT  - JOURNAL ARTICLE
AU  - Talal M. Karima
AU  - Syed Z. Bukhari
AU  - Mohammad A. Ghais
AU  - Mohammad I. Fatani
AU  - Waleed M. Hussain
TI  - Prevalence of Helicobacter pylori infection in patients with peptic ulcer diseases
DP  - 2006 May 01
TA  - Saudi Medical Journal
PG  - 621--626
VI  - 27
IP  - 5
4099  - http://smj.org.sa/content/27/5/621.short
4100  - http://smj.org.sa/content/27/5/621.full
SO  - Saudi Med J2006 May 01; 27
AB  - OBJECTIVE: To determine the prevalence of Helicobacter pylori (H. pylori) infection among patients presenting with peptic ulcer disease (PUD) and to establish the relationship between H. pylori infection and its diverse pathology. Secondly, we aimed to examine the effect of age, gender, and geographical distribution on the prevalence of the disease.METHODS: The study included patients with PUD who underwent upper gastrointestinal endoscopy at Hera General Hospital, Makkah, Kingdom of Saudi Arabia between January 2003 and February 2004. We tested the biopsies for the detection of H. pylori by Campylobacter like organism (CLOTM) test, histopathology, immunoglobulin G (IgG) antibodies, culture, and antimicrobial susceptibility testing.RESULTS: The overall prevalence rate of H. pylori infection among 132 patients with PUD was 63%, while it was high among females (70%) as compared with males (58%). The H. pylori were mainly found in chronic active gastritis (89%) and severe active gastritis (96%). Helicobacter pylori were documented by CLOTM test in 73 (55.3%) cases, histopathology in 69 (52.3%) cases, microbiological culture in 59 (44.7%) cases, and IgG antibodies in 61 (46.2%) cases. The highest resistance (31%) was found in metronidazole, while lowest the (3%) in tetracycline and erythromycin.CONCLUSION: The highest prevalence of H. pylori was found in the younger age group with female preponderance. The leading causes of multifocal pathology were chronic and severe active gastritis secondary to H. pylori infection.