RT Journal Article SR Electronic T1 Squamous cell carcinoma of colon and rectum JF Saudi Medical Journal JO Saudi Med J FD Prince Sultan Military Medical City SP 874 OP 877 VO 27 IS 6 A1 Fraz Fahim A1 Saleh M. Al-Salamah A1 Muhammad K. Alam A1 Muhammad H. Al-Akeely YR 2006 UL http://smj.org.sa/content/27/6/874.abstract AB Primary squamous cell carcinoma SCC of the colon and rectum is a rare malignancy. Less than 100 cases have been reported in literature. We report 2 cases of pure SCC involving the rectum and sigmoid colon. A review of literature has been made starting from the first report in 1919 to the present. We have examined the theories regarding the etiology, available treatment modalities, and prognosis for this variant of colorectal carcinoma. We conclude that this tumor presents later than adenocarcinoma and follows an aggressive course. With a greater awareness among surgeons and pathologists, more cases may become known leading to a better estimation of prevalence and clinicopathological behavior of this tumor.