RT Journal Article
SR Electronic
T1 Effects of salmon calcitonin on fracture healing in ovariectomized rats
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 60
OP 64
VO 28
IS 1
A1 Li, Xiaolin
A1 Luo, Xinle
A1 Yu, Nansheng
A1 Zeng, Bingfang
YR 2007
UL http://smj.org.sa/content/28/1/60.abstract
AB OBJECTIVE: To explore the effects of salmon calcitonin on the healing process of osteoporotic fractures in ovariectomized rats.METHODS: We performed this study in The First Affiliated Hospital of Guangzhou Medical College, Guangzhou, China, during the period March 2002 to December 2004. We used 120 female adult Wistar rats in this experiment, among which 90 underwent ovariectomy (OVX) and the other 30 had sham-operation. All rats had their left tibias fractured 3 months later. The 90 OVX rats were randomly divided into 3 groups with 30 in each, while the 30 sham-operated rats served as control group. After the fracture the rats had subcutaneous injection of normal saline, salmon calcitonin and estrogen, respectively. X-ray film, histological examination, bone mineral density (BMD) measurement and biomechanics testing were carried out to evaluate the fracture healing.RESULTS: Compared with OVX rats treated with normal saline, the rats with salmon calcitonin had significantly higher BMD values in the left tibia, higher max torque, shear stress of the left tibia 8 weeks after fracture (p<0.05), and presented with stronger callus formation, shorter fracture healing time and faster normalization of microstructure of bone trabeculae.CONCLUSION: Salmon calcitonin can, not only increase BMD in osteoporotic bone, but also enhance the bone biomechanical properties and improve the process of fracture healing in fractured osteoporotic bone.