PT - JOURNAL ARTICLE AU - Askar, Akram M. TI - Hyperphosphatemia AID - 10.15537/smj.2015.1.9843 DP - 2015 Jan 01 TA - Saudi Medical Journal PG - 13--19 VI - 36 IP - 1 4099 - http://smj.org.sa/content/36/1/13.short 4100 - http://smj.org.sa/content/36/1/13.full SO - Saudi Med J2015 Jan 01; 36 AB - Hyperphosphatemia is a major cause of morbidity and mortality in patients with chronic kidney disease. The association between hyperphosphatemia and increased risk of death from cardiovascular disease/vascular calcification has been well established for a long time. This review explores the new aspects of pathogenesis of vascular calcification, as demonstrated by recent advances showing a recognized regulating role of phosphorus in vascular smooth muscle cell calcification. This novel mechanism may help in finding a new pharmacological therapy to reduce, or prevent blood vessel calcification. Furthermore, recent experimental and clinical studies involved in the treatment of hyperphosphatemia are reviewed in this article.