PT  - JOURNAL ARTICLE
AU  - Askar, Akram M.
TI  - Hyperphosphatemia
AID  - 10.15537/smj.2015.1.9843
DP  - 2015 Jan 01
TA  - Saudi Medical Journal
PG  - 13--19
VI  - 36
IP  - 1
4099  - http://smj.org.sa/content/36/1/13.short
4100  - http://smj.org.sa/content/36/1/13.full
SO  - Saudi Med J2015 Jan 01; 36
AB  - Hyperphosphatemia is a major cause of morbidity and mortality in patients with chronic kidney disease. The association between hyperphosphatemia and increased risk of death from cardiovascular disease/vascular calcification has been well established for a long time. This review explores the new aspects of pathogenesis of vascular calcification, as demonstrated by recent advances showing a recognized regulating role of phosphorus in vascular smooth muscle cell calcification. This novel mechanism may help in finding a new pharmacological therapy to reduce, or prevent blood vessel calcification. Furthermore, recent experimental and clinical studies involved in the treatment of hyperphosphatemia are reviewed in this article.