PT  - JOURNAL ARTICLE
AU  - Alkhenizan, Abdullah H.
AU  - Alswes, Mohammed A.
TI  - The role of renin blockers in the prevention of diabetes
DP  - 2007 Jan 01
TA  - Saudi Medical Journal
PG  - 91--95
VI  - 28
IP  - 1
4099  - http://smj.org.sa/content/28/1/91.short
4100  - http://smj.org.sa/content/28/1/91.full
SO  - Saudi Med J2007 Jan 01; 28
AB  - OBJECTIVE: To evaluate the role of renin blockers angiotensin converting enzymes inhibitors (ACEI) or angiotensin receptor blockers (ARB) in the prevention of diabetes.METHODS: We did a meta-analysis using the Cochrane group methodology of all available randomized controlled trials (RCTs) that evaluated the role of renin blockers in which outcomes of new-onset diabetes was reported. This meta-analysis was conducted between April 2005-April 2006 at King Faisal Specialist Hospital and Research Center, Riyadh, Kingdom of Saudi Arabia.RESULTS: Thirteen trials including 91,388 individuals met the inclusion criteria. There was a statistically significant reduction in the incidence of new-onset diabetes in patients receiving renin blockers compared to other antihypertensive agents [relative risks=0.79; 95% confidence interval=0.75-0.84). There was a statistically significant reduction in the incidence of new-onset diabetes in patients receiving renin-blockers compared to diuretics, conventional antihypertensive therapy (diuretics or beta-blockers), and calcium channel blockers.CONCLUSION: Renin blockers reduce the incidence of new-onset diabetes and should be considered as first line therapy, when indicated, in patients at high risk for diabetes.