PT  - JOURNAL ARTICLE
AU  - Al-Agha, Abdulmoein E.
AU  - Hayatalhazmi, Rahaf S.
TI  - Osteoporosis treatment with zoledronic acid in pediatric population at a university hospital in Western Saudi Arabia
AID  - 10.15537/smj.2015.11.12590
DP  - 2015 Nov 01
TA  - Saudi Medical Journal
PG  - 1312--1318
VI  - 36
IP  - 11
4099  - http://smj.org.sa/content/36/11/1312.short
4100  - http://smj.org.sa/content/36/11/1312.full
SO  - Saudi Med J2015 Nov 01; 36
AB  - Objectives: To highlight the clinical benefit, efficacy, and safety of zoledronic acid (ZA) therapy in children and adolescents with primary and secondary osteoporosis.Methods: This is a retrospective observational study of 131 children and adolescents visiting the Pediatric Endocrine Clinic at King Abdulaziz University Hospital, Jeddah, Kingdom of Saudi Arabia, between January 2002 and January 2015. Clinical and laboratory data were collected for each patient and adverse events were evaluated.Results: The mean patient age was 11.43 years. There was a significant decrease in the number of fractures after ZA treatment for primary osteoporosis (p=0.000) and in secondary osteoporosis (p=0.005). There was a significant decrease in both osteocalcin (p=0.001) and C-terminal telopeptide (p=0.003) in patients with primary osteoporosis, as well as osteocalcin (p=0.003) and C-terminal telopeptide (p=0.008) in patients with secondary osteoporosis after treatment.Conclusion: The use of ZA in children and adolescent appears to have favorable effects on fracture rate and quality of life, including pain and mobility in symptomatic individuals. Intravenous ZA is comparable to other bisphosphonate agents in its efficacy and safety and features a more convenient infusion protocol with no documented long-term complications, thus, we advise its use in pediatric population.