PT  - JOURNAL ARTICLE
AU  - Javadzadeh, Alireza
AU  - Ghorbanihaghjo, Amir
AU  - Rashtchizadeh, Nadereh
AU  - Rafeey, Mandana
AU  - Rahimi-Ardabili, Babak
TI  - Enhanced susceptibility of low-density lipoprotein to oxidation in wet type age-related macular degeneration in male patients.
DP  - 2007 Feb 01
TA  - Saudi Medical Journal
PG  - 221--224
VI  - 28
IP  - 2
4099  - http://smj.org.sa/content/28/2/221.short
4100  - http://smj.org.sa/content/28/2/221.full
SO  - Saudi Med J2007 Feb 01; 28
AB  - OBJECTIVES: To determine the susceptibility of low-density lipoprotein (LDL) to oxidation in the plasma of male patients with wet type age related macular degeneration (AMD) and in a similar control group, in order to evaluate the LDL oxidative status as risk factor of AMD.METHODS: We conducted this study in the Retina Service, Department of Ophthalmology, Nikookari Eye Hospital-Drug of Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran during the period between October 2004 and December 2005. Sixty male patients with AMD (mean age 67 ± 16 years) with BMI 4.1 ± 1.3 were selected as the patient group. The control group consisted of 60 males, apparently healthy, and without ophthalmologic signs and family history of AMD. Low-density lipoprotein was isolated by gradient ultracentrifugation and susceptibility of LDL to in vitro copper-mediated oxidation was assayed by measuring conjugated dienes production (lag phase duration) at 234 nm. Lipid and lipoproteins were determined by standard methods.RESULTS: Comparing with control, significant reduction in the duration of lag phase (p<0.004) and a significant increase in LDL-C concentrations (p=0.006), were noticed. No significant change in cholesterol (p>0.3), triglyceride (p>0.1) and high density lipoprotein cholesterol (p>0.1) levels were found between control and patient groups. A significant negative correlation between Lag phase and LDL-C levels (p=0.004, r=-0.364) was found in the patient group.CONCLUSIONS: The increased LDL concentration and enhanced susceptibility of LDL to oxidation may play a roll in the wet type AMD process.