PT  - JOURNAL ARTICLE
AU  - Oc, Mehmet
AU  - Ucar, Halil Ibrahim
AU  - Pinar, Asli
AU  - Akbulut, Birkan
AU  - Oc, Bahar
AU  - Akinci, Seda Banu
AU  - Akyon, Yakut
AU  - Kanbak, Meral
AU  - Boke, Erkmen
AU  - Dogan, Riza
TI  - Heat shock protein 60 antibody. A new marker for subsequent atrial fibrillation development
DP  - 2007 Jun 01
TA  - Saudi Medical Journal
PG  - 844--847
VI  - 28
IP  - 6
4099  - http://smj.org.sa/content/28/6/844.short
4100  - http://smj.org.sa/content/28/6/844.full
SO  - Saudi Med J2007 Jun 01; 28
AB  - OBJECTIVE: To examined the pre- and post- operative anti-HSP60 antibodies of serum from patients in preoperative sinus rhythm.METHODS: We prospectively studied 45 consecutive patients admitted for elective CABG from 2004 to 2005. We randomly selected 10 patients developing AF (study sample [Group A]) and 10 postoperative patients without AF (control [Group B]. The study took place at the Department of Cardiovascular Surgery, Hacettepe University, Ankara, Turkey.RESULTS: Anti-HSP60 IgG value was 27.76 ± 12.69 absorbance units (AU) in Group A preoperatively and decreased to 13.73 ± 5.51 AU postoperatively. Controversially, preoperative value of anti-HSP60 IgG was 9.94 ± 2.92 AU and decreased to 6.72 ± 1.89 AU, postoperatively in Group B. Statistical analysis showed significant difference regarding preoperative anti-HSP60 IgG levels in Group A compared to Group B, which might be interpreted as an association between postoperative AF and preoperative levels of anti-HSP60 IgG.CONCLUSION: We provide the first evidence demonstrating the association of pre- and post- operative circulating anti-HSP60 antibodies with postoperative AF. These results suggest that serum HSP60 antibody levels may be a marker for subsequent development of AF.