RT Journal Article
SR Electronic
T1 Heat shock protein 60 antibody. A new marker for subsequent atrial fibrillation development
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 844
OP 847
VO 28
IS 6
A1 Oc, Mehmet
A1 Ucar, Halil Ibrahim
A1 Pinar, Asli
A1 Akbulut, Birkan
A1 Oc, Bahar
A1 Akinci, Seda Banu
A1 Akyon, Yakut
A1 Kanbak, Meral
A1 Boke, Erkmen
A1 Dogan, Riza
YR 2007
UL http://smj.org.sa/content/28/6/844.abstract
AB OBJECTIVE: To examined the pre- and post- operative anti-HSP60 antibodies of serum from patients in preoperative sinus rhythm.METHODS: We prospectively studied 45 consecutive patients admitted for elective CABG from 2004 to 2005. We randomly selected 10 patients developing AF (study sample [Group A]) and 10 postoperative patients without AF (control [Group B]. The study took place at the Department of Cardiovascular Surgery, Hacettepe University, Ankara, Turkey.RESULTS: Anti-HSP60 IgG value was 27.76 ± 12.69 absorbance units (AU) in Group A preoperatively and decreased to 13.73 ± 5.51 AU postoperatively. Controversially, preoperative value of anti-HSP60 IgG was 9.94 ± 2.92 AU and decreased to 6.72 ± 1.89 AU, postoperatively in Group B. Statistical analysis showed significant difference regarding preoperative anti-HSP60 IgG levels in Group A compared to Group B, which might be interpreted as an association between postoperative AF and preoperative levels of anti-HSP60 IgG.CONCLUSION: We provide the first evidence demonstrating the association of pre- and post- operative circulating anti-HSP60 antibodies with postoperative AF. These results suggest that serum HSP60 antibody levels may be a marker for subsequent development of AF.