PT  - JOURNAL ARTICLE
AU  - Alshemmari, Salem H.
AU  - Ameen, Reem M.
AU  - Gyrafas, Jan
AU  - Alqallaf, Dana A.
AU  - Sajnani, Kamlesh P.
TI  - Factors influencing engraftment in autologous peripheral stem cell transplantation. The experience of a local Kuwaiti transplantation center
DP  - 2007 Jul 01
TA  - Saudi Medical Journal
PG  - 1080--1085
VI  - 28
IP  - 7
4099  - http://smj.org.sa/content/28/7/1080.short
4100  - http://smj.org.sa/content/28/7/1080.full
SO  - Saudi Med J2007 Jul 01; 28
AB  - OBJECTIVE: To assess factors affecting engraftment among patients with lymphoproliferative disorders treated with high dose-chemotherapy and autologous peripheral blood stem cell transplantation.METHODS: Fifty-four patients with lymphoproliferative disorders were treated from March 2000 to April 2006, at the Hamid Al-Essa Multiorgan Transplant Center, Kuwait. There were 37 males and 17 females, with a median age of 43 years (range 12-60). The cohort included 13 Hodgkin's lymphoma, 31 non-Hodgkin's lymphoma, and 10 multiple myeloma cases.RESULTS: The median number of infused CD34+ cells was 1.7 x 106 per kg (0.38-15). The medians for absolute neutrophil count (ANC) and platelet (PLT) engraftment were 12 days (10-15) and 11 days (6-33). The CD34+ cell dose and timing of granulocyte-colony stimulating growth factor administration had no significant influence on ANC engraftment (p=0.3 and p=0.05).CONCLUSION: The results imply that the CD34+ cell dose is the most important predictor of hematopoietic engraftment, namely PLT engraftment. The other factors studied had no clear influence on engraftment kinetics in this cohort.