RT Journal Article
SR Electronic
T1 Comparative assessment of induction efficacy of propofol preparations
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 1055
OP 1058
VO 28
IS 7
A1 Oz, Goksen
A1 Uzun, Sennur
A1 Dal, Didem
A1 Akinci, Seda B.
A1 Aypar, Ulku
YR 2007
UL http://smj.org.sa/content/28/7/1055.abstract
AB OBJECTIVE: To compare the hypnotic effects (using Bispectral Index [BIS]), hemodynamic parameters, injection pain and quality of anesthesia during induction of anesthesia of the 3 commercial propofol preparations (Abbott Propofol, Abbott Laboratories), Pofol (Dongkook Pharm. Co. Ltd.), and Propofol 1% Fresenius (Fresenius Kabi).METHODS: After Ethics Committee Approval, a prospective, randomized, double-blind study was designed in Hacettepe University Hospitals Operating Theaters in 2005. The patients aged 18-65 years, American Society of Anesthesiologists (ASA) grades I and II scheduled for elective surgery under general anesthesia with orotracheal intubation. Ninety patients were randomized into 3 groups with 30 patients in each group. Propofol infusion rate was 2.5 mg. seconds-1. Induction time and doses to reach BIS level of 50 ± 10, injection pain, BIS values and hemodynamic parameters were recorded every minutes for the first 7 minutes and than every 2 minutes for 15 minutes. We used a special chart to assess the induction quality.RESULTS: Demographical parameters and ASA Physical status were similar in all groups. There were no significant differences in induction quality, induction time and doses, injection pain, BIS values and hemodynamic parameters.CONCLUSION: Abbott Propofol, Pofol and Propofol 1% Fresenius have similar effects on anesthesia induction quality and the cost should be taken into consideration when choosing the type of commercial formulation propofol emulsions.