PT  - JOURNAL ARTICLE
AU  - Soveid, Mahmood
AU  - Monabbati, Ahmad
AU  - Sooratchi, Leyla
AU  - Dahti, Sara
TI  - The effect of iodine prophylaxis on the frequency of thyroiditis and thyroid tumors in Southwest, Iran
DP  - 2007 Jul 01
TA  - Saudi Medical Journal
PG  - 1034--1038
VI  - 28
IP  - 7
4099  - http://smj.org.sa/content/28/7/1034.short
4100  - http://smj.org.sa/content/28/7/1034.full
SO  - Saudi Med J2007 Jul 01; 28
AB  - OBJECTIVE: To investigate the effect of the salt iodization program, which was initiated in 1989 on frequencies of thyroiditis and papillary carcinoma in Fars province of Iran, which was previously an iodine deficient area.METHODS: Four hundred and eighty-two thyroidectomy specimens belonging to the pre-iodization period from 1983 to 1988, and 466 post iodization specimens from 1998 to 2003 were re-examined for presence of lymphocytic infiltration and types of thyroid tumors. This study was carried out in Shiraz University of Medical Sciences, Iran.RESULTS: The frequency of lymphocytic infiltration in non-neoplastic specimens increased from 30-60.5% after salt iodization (p<0.001). Background of lymphocytic infiltration in neoplastic specimens also increased from 18.5-61% after iodine prophylaxis (p<0.001). The frequency of papillary carcinoma in neoplastic specimens increased from 15-43% (p=0.01) and that of follicular adenoma decreased from 69-32.5% (p<0.0001).CONCLUSION: Salt iodization is associated with an increased occurrence of histologic thyroiditis and papillary carcinoma.