PT  - JOURNAL ARTICLE
AU  - Alenzi, Faris Q.
AU  - Wyse, Richard K.
AU  - Tamimi, Waleed G.
AU  - Bamaga, Mohammad S.
AU  - Lotfy, Mahmoud
TI  - A close link between Fas, p53 and Apaf-1 in chronic myeloid leukemia
DP  - 2007 Jul 01
TA  - Saudi Medical Journal
PG  - 1119--1121
VI  - 28
IP  - 7
4099  - http://smj.org.sa/content/28/7/1119.short
4100  - http://smj.org.sa/content/28/7/1119.full
SO  - Saudi Med J2007 Jul 01; 28
AB  - In chronic myeloid leukemia CML proliferation is increased and resistance to apoptosis has been proposed as a mechanism accounting for myeloid cell expansion. There is still controversy on whether apoptosis plays an important role in the regulation of myelopoiesis. This study aims to investigate whether apoptosis-related proteins play a role in the evolution of CML and to identify, the relationship between Fas, p53 and apoptosis protease activating factor Apaf-1 in CML. We found increased p53 and Apaf-1 messenger ribonucleic acid mRNA in patients with CML. However, one patient, who had a p53 point mutation, showed a massive elevation of p53 mRNA during blast crisis yet, conversely, a considerable reduction in Apaf-1 mRNA and Fas mRNA. Our results show an in-vivo linkage between Fas, p53 and Apaf-1 transcription regulation. This suggests that key genes involved in apoptosis are also involved in CML disease progression.