RT Journal Article
SR Electronic
T1 A close link between Fas, p53 and Apaf-1 in chronic myeloid leukemia
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 1119
OP 1121
VO 28
IS 7
A1 Alenzi, Faris Q.
A1 Wyse, Richard K.
A1 Tamimi, Waleed G.
A1 Bamaga, Mohammad S.
A1 Lotfy, Mahmoud
YR 2007
UL http://smj.org.sa/content/28/7/1119.abstract
AB In chronic myeloid leukemia CML proliferation is increased and resistance to apoptosis has been proposed as a mechanism accounting for myeloid cell expansion. There is still controversy on whether apoptosis plays an important role in the regulation of myelopoiesis. This study aims to investigate whether apoptosis-related proteins play a role in the evolution of CML and to identify, the relationship between Fas, p53 and apoptosis protease activating factor Apaf-1 in CML. We found increased p53 and Apaf-1 messenger ribonucleic acid mRNA in patients with CML. However, one patient, who had a p53 point mutation, showed a massive elevation of p53 mRNA during blast crisis yet, conversely, a considerable reduction in Apaf-1 mRNA and Fas mRNA. Our results show an in-vivo linkage between Fas, p53 and Apaf-1 transcription regulation. This suggests that key genes involved in apoptosis are also involved in CML disease progression.