RT Journal Article
SR Electronic
T1 Actual antibiotic resistance pattern of Brucella melitensis in central Anatolia. An update from an endemic region
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 1239
OP 1242
VO 28
IS 8
A1 Tanyel, Esra
A1 Coban, Ahmet Y.
A1 Koruk, Suda T.
A1 Simsek, Husniye
A1 Hepsert, Serkan
A1 Cirit, Osman S.
A1 Tulek, Necla
YR 2007
UL http://smj.org.sa/content/28/8/1239.abstract
AB OBJECTIVE: To test in vitro susceptibilities of Brucella melitensis (B. melitensis) blood isolates obtained from an endemic region, by broth microdilution susceptibility test.METHODS: Fifty blood isolates were tested with anti-brucella antibiotics, namely, tetracycline, gentamicin, streptomycin, ceftriaxone, ciprofloxacin, levofloxacin, ofloxacin, and rifampin. All of the clinical isolates belonged to the group of B. melitensis biotype-3. This study was performed at the Clinical Microbiology Laboratory of the Medical School of Ondokuz Mayis University, Samsun, Turkey, in 2005.RESULTS: In terms of minimum inhibitory concentration-90 (MIC90) values, tetracycline (MIC90 0.25 microgram/mL) and rifampin (MIC90 0.5 microgram/mL) still continue to be the most effective antibiotics; however, ceftriaxone and streptomycin demonstrated higher MIC values, although they were still effective in vitro against B. melitensis strains with MIC90 of 8 microgram/mL.CONCLUSION: All first line, and alternative antimicrobial agents could be used in various combinations in the treatment of human brucellosis. High MIC values of ceftriaxone and streptomycin are alarming, and should be closely monitored during the therapy.