RT Journal Article
SR Electronic
T1 Effects of intraarticular contrast media on synovial membrane and cartilage. An electron microscopic evaluation in rabbit knees
JF Saudi Medical Journal
JO Saudi Med J
FD Prince Sultan Military Medical City
SP 713
OP 716
VO 28
IS 5
A1 Kose, Nusret
A1 Inan, Ulukan
A1 Baycu, Cengiz
A1 Omeroglu, Hakan
A1 Seber, Sinan
YR 2007
UL http://smj.org.sa/content/28/5/713.abstract
AB OBJECTIVE: To evaluate the histological and ultrastructural alterations in rabbit knee joint cartilage and synovia induced by intraarticular injections of 2 water soluble contrast agents.METHODS: The study was conducted at the Department of Orthopedics and Traumatology, Medical Faculty, Osmangazi University, Eskisehir, Turkey in January 2002. To examine the effect of contrast agents on articular cartilage and synovial membrane, rabbit model was used. Specimens from 62 knee joints were examined by light microscopy and transmission electron microscopy one hour, one day, one week and 2 weeks after intraarticular administration of gadolinium-diethylenetriamine pentaacetic acid, iopromide or saline.RESULTS: In the knees injected with saline, light microscopic changes of the synovium consisted of edema only. Edema and hyperemia were seen in contrast agent injected knees. Ultrastructurally, numerous and large pinocytotic vesicles in A cells of the synovial membrane were seen in contrast agent injected groups. In the knees injected with saline the cartilage were ultrastructurally normal but contrast agent injected knees showed increased activation of chondrocytes with increase of dense glycogen accumulation, large lipid vacuoles and matrix material. There were very rare pycnotic cells in these samples. The rating scale has been used and the means of the total scores were determined for the groups.CONCLUSION: The effects of contrast agents reduced gradually on the cartilage and synovium in general but did not become completely normal in the observation period.