- Glutathione-related plasma and placental enzyme activities in IUGR and healthy pregnant (HP) groups.
| Enzyme/units | HP group (n=25) | IUGR group (n=25) | P-value |
|---|---|---|---|
| Plasma GPx/nmol/min/ml | 1.30 ± 0.16 | 1.15 ± 0.13* | 0.0007 |
| Placental GPx/µmol/min/mg protein | 0.50 ± 0.06 | 0.29 ± 0.03† | 0.0001 |
| Plasma GR/nmol/min/ml | 2.08 ± 0.28 | 1.80 ± 0.25* | 0.0005 |
| Placental GR/µmol/min/mg protein | 0.85 ± 0.11 | 0.48 ± 0.06† | 0.0001 |
| Plasma GST/pmol/min/ml | 65.1 ± 8.46 | 57.30 ± 7.37* | 0.0010 |
| Placental GST/nmol/min/mg protein | 23.7 ± 2.95 | 13.7 ± 1.60† | 0.0001 |
| Plasma GCL/pmol/min/ml | 418 ± 89.3 | 342 ± 68.3* | 0.0014 |
| Placental GCL/nmol/min/mg protein | 236 ± 40.7 | 112 ± 18.9† | 0.0001 |
| Plasma GS/nmol/min/ml | 3.56 ± 0.48 | 3.09 ± 0.42* | 0.0006 |
| Placental GS/nmol/min/mg protein | 612 ± 79.1 | 386 ± 43.4† | 0.0001 |
Values are presented as mean ± SD. *p<0.001; †p<0.0001, IUGR: intrauterine growth restriction, GST: glutathione-S-transferase, GPx: glutathione peroxidase, GR: glutathione reductase, GS: glutathione synthetase