- Plasma and placental GSH and GSSG levels and the GSH/GSSG ratio in IUGR and health pregnant (HP) groups.
| Oxidative stress markers | HP group (n=25) | IUGR group (n=25) | P-value |
|---|---|---|---|
| Plasma GSH µM | 2.85 ± 0.37 | 2.50 ± 0.31* | 0.0006 |
| Placental GSH nmol/mg tissue | 6.21 ± 0.86 | 4.88 ± 0.71† | 0.0001 |
| Plasma GSSG µM | 0.059 ± 0.009 | 0.069 ± 0.011* | 0.0009 |
| Placental GSSG nmol/mg tissue | 0.13 ± 0.017 | 0.17 ± 0.023† | 0.0001 |
| Plasma GSH/GSSG | 48.3 ± 6.5 | 27.8 ± 3.73† | 0.0001 |
| Placental GSH/GSSG | 44.6 ± 6.10 | 28.7 ± 3.88† | 0.0001 |
Values are presented as mean ± SD. *p<0.001; †p<0.0001, IUGR: intrauterine growth restriction, GSH: glutathione, GSSG: oxidized glutathione