- Covariates associated with overall mortality in the time-dependent Cox model.
| Covariates | Hazard ratio (95%CI) | P-value |
|---|---|---|
| Main coefficients | ||
| TNM Staging | <0.001 | |
| 1 | (reference) | |
| 0 | NA (NA) | 1 |
| 2 | 3.53 (0.4, 31.48) | 0.2 |
| 3 | 17.45 (1.72, 177.36) | 0.016 |
| 4 | 73.63 (7.07, 766.46) | <0.001 |
| Nodal type | 0.068 | |
| Negative | (reference) | |
| Positive | 8.93 (0.65, 122.62) | 0.01 |
| ER receptor type | ||
| Negative | (reference) | |
| Positive | 0.31 (0.18, 0.54) | <0.001 |
| Tumour size | 1.4 (1.14, 1.71) | 0.002 |
| Age (years) | 0.003 | |
| >70 | (reference) | |
| <30 | 1.24 (0.26, 6.03) | 0.787 |
| 30-39 | 0.13 (0.04, 0.44) | 0.001 |
| 40-49 | 0.22 (0.09, 0.55) | 0.001 |
| 50-59 | 0.4 (0.17, 0.94) | 0.035 |
| 60-69 | 0.29 (0.11, 0.79) | 0.015 |
| Time-varying coefficients | ||
| Nodal status | ||
| Negative | (reference) | |
| Positive | 0.24 (0.08, 0.76) | 0.015 |
ER: estrogen receptor, NA: not applicable, TNM: tumor, nodal, metastasis