- Effect of non-synonymous polymorphisms on structure, function and stability of TLR2 protein.
| Mutation name | Tools | |||||||
|---|---|---|---|---|---|---|---|---|
| PROVEAN | MUPRO | SIFT | FATHMM | POLYPHEN-2 | ||||
| Score | Prediction | Prediction | ΔΔ D | Prediction | Score | Prediction | Prediction | |
| T513A | -0.517 | Neutral | Decrease stability | -0.906 | Tolerated | 0.28 | Tolerated | Benign |
| L603M | -962 | Neutral | Decrease stability | -1.458 | Tolerated | 1.22 | Tolerated | Benign |
TLR2: toll-like receptor -2, PROVEAN: Protein variation effect analyzer, SIFT: sorting intolerant from tolerant, FATHMM: functional analysis through hidden Markov models, POLYPHEN-2: polymorphism phenotyping v2