StudyStudy designNumberGender (male/female)Age (years), median (range) or mean±SDNationalityParticipantsCollecting methodCorrelationTPFNFPTN
Williams et al,10case-control89NRNRAustraliasymptomaticOnly oral cavity saliva 336149
Landry et al,13cohort124NRNRUSA0.851305089
Griesemer et al,19463246/11714-77USAmixedOral cavity saliva (not defined)911413345
Bhattacharya et al,25case-control74NRNRIndiasymptomatic5350106
Byrne et al,26cohort11061/49NREnglandOnly oral cavity saliva122096
Caulley et al,201939NRNRCanadamixed3422141869
Hanson et al,14354188/16635 (18-75)USAsymptomatic0.9127556268
Moreno-Contreras et al,12182116/13741±14.4MexicoOral cavity saliva (not defined) 411128102
Pasomsub et al,7cross-sectional20069/13136 (28-48)ThailandOnly oral cavity saliva0.8511632179
Skolimowska et al,11cohort13143/8939 (30-51)England 1531112
Vaz et al,1615546/10340 (33-48.5)Brazil0.922674282
Yokota et al,8 (airport)1763927/832/4 (unknown)33.5 (22.6-47.4)JapanasymptomaticOral cavity saliva (not defined)4101758
Yokota et al,8 (contact)16144/26/91 (unknown)44.9 (29.8-66.4)Japan3836114
Güçlü et al,17cross-sectional6437/2751.04±17.9Turkeysymptomatic0.744234433
Senok et al,21401329/7235.5±9.5UAEasymptomaticOnly oral cavity saliva0.681979366
Altawalah et al,18891NRNRKuwaitsymptomaticEnhanced saliva0.8142875718529
Procop et al,15224NRNRUSAsymptomatic 3801177
Kandel et al,23cohort429295/13442 (30-54)CanadamixedOnly oral cavity saliva0.913943383
Braz-Silva et al,2420175/12640 (31-52)Brazilsymptomatic55150131
Babady et al,2287NRNRUSAEnhanced saliva161169
Dogan et al,27cross-sectional98NRNRTurkeyOnly oral cavity saliva3025538
Wong et al,28retrospective229NRNRChinamixed104183770
Iwasaki et al,29cross-sectional66NRNRJapansymptomatic0.87481166
Kojima et al,30prospective cross-sectional45NR45 (21-53)USAEnhanced saliva203616
McCormick-Baw et al,31155NRNRUSAOnly oral cavity saliva (not defined)4721105
Miller et al,32cross-sectional91NRNRUSAmixedOnly oral cavity saliva331156
Vogels et al,33prospective cross-sectional67NRNRUSAOnly oral cavity saliva (not defined)322330
Boerger et al,34281NRNRUSAOnly oral cavity saliva3032246
Toppings et al,35cross-sectional63NRNRCanada282033
Xun et al,36104NRNRUSA282173
Masse et al,37prospective cross-sectional14363/8035 (22.5-49)FrancesymptomaticEnhanced saliva0.89515285
Sasikala et al,38200140/6037.9±12.8Indiamixed 12846026
Mohd Thabit et al,399666/3034±26 (12-95)MalaysiaOnly oral cavity saliva0.694511436
Fernandes et al,40cohort22691/135NRPortugal 67134142
Marx et al,41cross-sectional730420/310NRUSAsymptomatic/mixed/asymptomatic0.924686436
Abasiyanik et al,42cohort92NR45 (30.58)USAsymptomatic160769
Alkhateeb et al,43prospective cross-sectional4826/2239.9±15.5USAsymptomatic/mixed/asymptomaticEnhanced saliva123018
Bidkar et al,44cross-sectional8049/3136.4IndiamixedOnly oral cavity saliva1328233
Stokes et al,45prospective cross-sectional14575/7039.4Canadasymptomatic1211725
Fernández-González et al,4622991/12839 (21-48)Spainmixed0.853974171
Herrera et al,48cross-sectional study2107NRNRMexicoasymptomatic0.85213934101867
Trobajo-Sanmartín et al,47prospective cross-sectional674374/300NRSpainmixed 1681563309
  • SD: standard deviation, TP: true positive, FN: false negative, FP: false positive, TN: true negative NR: not reported