Table 2

- Comparison of fibrosis grades between the study groups.

Groups	Grade I	Grade II	Grade III	Mean±SD	Groups differences	P-value*
Groups	Grade I	n (%)	Grade III	Mean±SD	Groups differences	P-value*
1 (n=8)		2 (25.0)	6 (75.0)	2.75±0.46	p<0.01^†	≤0.001
2 (n=8)		3 (37.5)	5 (62.5)	2.63±0.52	p<0.01^‡
3 (n=8)	2 (25)	4 (50.0)	2 (25.0)	2.00±0.76	-
4 (n=8)	3 (37.5)	5 (62.5)		1.63±0.52	p<0.01^†, p<0.01^‡

Data are presented as number and precentage. One way ANOVA with Tukey post hoc test was used to assess differences between the groups. ^†Group 1 versus group 4, ^‡group 2 versus group 4, *comparison of fibrosis grades between groups, group 1: control, group 2: spongostane group, group 3: low-dose berberine (BBR), group 4: high-dose BBR, SD: standard deviation