Table 3

- Characteristics of the study sample stratified by the cytochrome P450 2D6 single nucleotide polymorphism genotypes.

Variables	CYP2D6 genotypes
	rs1080985		rs28624811		rs1065852		rs28371725		rs1135840
	0 (n=56)	1 (n=51)	0 (n=30)	1 (n=77)	0 (n=80)	1 (n=27)	0 (n=76)	1 (n=31)	0 (n=40)	1 (n=67)
Age, mean±SD	38.5±10.4	36.6±12.2	37.1±10.1	37.8±11.8	38.7±11.4	34.3±10.8	37.6±11.1	37.5±12.1	35.4±11.1	38.9±11.3
P-values	0.37		0.77		0.08		0.97		0.12
Gender (n=91)	48	43	26	65	67	24	67	24	34	57
P-values	0.84		0.77		0.52		0.16		0.99
Cutaneous (n=83)	45	38	25	58	61	22	59	24	31	52
P-values	0.47		0.37		0.57		0.98		0.99
Arthritis (n=86)	44	42	23	63	62	24	61	25	33	53
P-values	0.62		0.55		0.20		0.96		0.67
Serositis (n=20)	6	14	4	16	18	2	15	5	8	12
P-values	0.03		0.37		0.08		0.66		0.79
Renal (n=50)	29	21	19	31	35	15	38	12	20	30
P-values	0.27		0.03		0.29		0.29		0.60
Neurological (n=19)	7	12	2	17	16	3	13	6	10	9
P-values	0.14		0.06		0.30		0.78		0.13
Hematological (n=47)	23	24	14	33	32	15	34	13	22	25
P-values	0.53		0.72		0.16		0.79		0.07
Immunological (n=92)	45	47	24	68	68	24	66	26	36	56
P-values	0.08		0.27		0.61		0.69		0.35
Values are presented as numbers or proportion in a subgroup. P-values (Bonferroni-adjusted) below 0.05 represents a statistically significant relationship (contingency) between CYP2D6 genotypes and participant characteristics. CYP2D6: cytochrome P450 2D6, SD: standard deviation, SNP: single nucleotide polymorphism, CYP2D6 SNP genotype 0: reference variant (homozygous dominant), CYP2D6 SNP genotype 1: alternative variants (heterozygous and homozygous recessive)