-Different studies of cytologically indeterminate thyroid nodules in Saudi Arabia.
| Study | Year | Bethesda category | Conclusions |
|---|---|---|---|
| Batawil and Alkordy12 | 2014 | III & IV | US has limited accuracy or predictive value. Surgery is the recommended treatment for indeterminate thyroid nodules. |
| Alqahtani et al13 | 2017 | III | Repeating FNAC has a significant role in discriminating benign from malignant nodules. No correlation between age or US variables and ROM. Men have a higher ROM. |
| Al Dawish et al24 | 2020 | III | ACR TI-RADS displays accurate diagnostic performance in predicting malignancy. |
| Al-Hakami et al14 | 2020 | III, IV, & V | The McGill Thyroid Nodule Score is helpful in preoperative decision-making in CITNs. |
| Alshahrani et al15 | 2021 | III | Irregular margins, microcalcifications, multiple nodules, and hypoechogenicities increase the ROM. |
| Alqahtani et al2 | 2022 | III & IV | None of the examined clinical or radiological features (ACR TI-RADS) contribute to the cancer risk stratification. |
| Alyousif et al16 | 2022 | III & IV | ACR TI-RADS is significantly correlated with the FNAC outcome and is a useful tool in the absence of molecular tests for thyroid cancer. |
| Alqahtani et al17 | 2022 | III | ACR TI-RADS does not help in cancer risk stratification. Repeated FNAC in AUS/FLUS nodules is recommended. |
ACR TI-RADS: American College of Radiology Thyroid Imaging Reporting and Data System, AUS: atypia of undetermined significance, CITN: cytologically indeterminate thyroid nodule, FLUS: follicular lesion of undetermined significance, FNAC: fine-needle aspiration cytology, ROM: risk of malignancy, US: ultrasound