Table 1

- Pharmacotherapy used in obesity management.

DrugsStarting dosesAvailable dosesSide effectsContraindications
Orlistat120mg TDS120 mgSteatorrhea, oil spots, faecal incontinence, fat-soluble vitamin malabsorption, and flatulence with dischargePregnancy
Liraglutide0.6 mg0.6-3mgNausea, vomiting, diarrhoea, constipation, pancreatitis (rare), and cholecystitis (rare)Severe renal or hepatic insufficiency, pregnancy, history of pancreatitis, and psychiatric disorder
Lorcaserin10 mg BID10 mgDry mouth, dizziness, somnolence, headache, and gastrointestinal disturbancesSevere renal insufficiency or severe hepatic impairment, pregnant
Phenteramine/topiramate15 mg/12.5 mgPhe-15 mg Topi-12.5, 25, 50, 100 mgDry mouth, insomnia, agitation, constipation, and tachycardiaSevere hypertension, cardiovascular disease, glaucoma, history of drug or alcohol abuse, monoamine oxidase inhibitors, selective serotonin reuptake inhibitor use, and pregnancy
Natrexone/bupropion8 mg/90 mgNal-8 mg Bup-90 mgConstipation, diarrhoea, nausea, vomiting, dizziness, and anxietyAcute opiate withdrawal, allergy to bupropion, bulimia, anorexia nervosa, history of seizure disorder, and uncontrolled hypertension
Semaglutide0.25 mg SQ once weekly then titrate2.4 mgHypoglycaemia, abdominal pain, constipation, and nauseaPersonal or family history of medullary thyroid carcinoma, known hypersensitivity to semaglutide
  • TDS: once 3 times a day, BID: twice a day, Phe: phenteramine, Topi: topiramate, Nal: naltrexone, Bup: bupropion, SQ: subcutaneous