- Case reports using phage therapy against MDR bacteria.
| Organism | Bacteriophage | Outcome | Reference |
|---|---|---|---|
| A. baumannii | Phage cocktail | The patient seemed to be more alert but still unresponsive No sign of infection at the craniotomy site was observed The patient’s fever and leckocytosis were persisted | (40) |
| UTI infection with P. aeruginosa | Phage cocktail | The combination of phage and antibiotics (colistin and meropenem) cured the UTI Led to a significant reduction of P. aeruginosa cells in the urine | (41) |
| MDR A. baumannii | Phage cocktail | The patient’s health significantly improved Phage cocktail led to clearance of the A. baumannii infection | (45) |
| Multidrug-resistant P. aeruginosa infection | Phage cocktail | Bacteriophage cocktail treatment led to better clinical outcomes Blood cultures were negative | (46) |
| P. aeruginosa infection | A single dose of phage OMKO1 and ceftazidime | The combination of phage OMKO1 and ceftazidime cured I infection | (47) |
| Drug-resistant Mycobacterium abscessus | 3 phage cocktail | Phage cocktail led to improved clinical outcomes including improved liver function and wound closure | (43) |
| Chronic methicillin-resistant S. aureus prosthetic joint infection | 3 IV doses of phage | Led to clearance of the severe chronic infection | (48) |
| Multidrug-resistant, carbapenemase (KPC-3)-producing K. pneumoniae | A custom-made, lytic bacteriophage | Eradicated the infection caused by K. pneumoniae and no adverse effects were observed | (49) |
MDR: Multidrug-resistant, A. baumannii: Acinetobacter baumannii, P. aeruginosa: Pseudomonas aeruginosa, S. aureus: Staphylococcus aureus, K. pneumoniae: Klebsiella pneumoniae, IV: intravenous, UTI: urinary tract infection