- Studies of antibiofilm activity of bacteriophages on biofilms formed by MDR isolates.
| Organism | Phage treatment | Outcome | Reference |
|---|---|---|---|
| MDR P. aeruginosa | MA1- | Reduction of 2.1-fold in a 24 hour (h) old biofilm, 2.5-fold in a 48 h old biofilm, and 3.2-fold in a 72 h old biofilm | (56) |
| MDR P. aeruginosa | vB_PaeM_LS1 | Eliminated preformed biofilm | (27) |
| MRSA | CSA13 | Reduced the biofilm biomass in a 24h biofilm by 93% | (60) |
| MDR E. cloacae | MJ2 | Reduction of 2.8-log in a 24 h old biofilm, 3-log in a 72 h old biofilm, and 3.5-log in 120 h old biofilm | (62) |
| MDR uropathogenic E. coli | vB_EcoP-EG1 | The phage eliminated 60% of a 24 h old biofilm developed by MG1655 and 50% of a 24 h old biofilm developed by 390G7 | (59) |
| MDR K. pneumoniae | Z | Reduction of 2-fold in a 24 h old biofilm and 3-fold in a 48 h old biofilm | (58) |
| MDR A. baumannii | Combination of bacteriophage cocktail and antibiotics | A synergistic effect between phage cocktail and some antibiotics caused a significant reduction in biofilm biomass formed by A. baumannii | (57) |
| MDR P. stuartii | Two lytic phages (PSTCR4 and PSTCR6) | Reduced P. stuartii biofilm cells by 2.86- and 2.46-log in latex and silicone catheters | (63) |
| MDR K. pneumoniae | Depolymerase (Dep42) | Dep42 significantly inhibited biofilm formation and degrade existed biofilms K. pneumoniae Dep42 enhanced polymyxin activity against biofilm formed by K. pneumoniae biofilms | (64) |
| MDR A. baumannii | Phage vABWU2101 | Phage vABWU2101 exhibited activity against both existed biofilm and biofilm formation, accounting for 18.77 to 70.25% reduction in formation of biofilm biomass and 9.43 to 52.43% reduction in existed biofilm biomass The combination treatment of phage vABWU2101 and tigecycline showed synergistic antibiofilm activity against biofilm formed by MDR A. baumanni | (65) |
MDR: Multidrug-resistant, P. aeruginosa: Pseudomonas aeruginosa, MRSA: Methicillin-resistant Staphylococcus aureus, E. cloacae: Enterobacter cloacae, E. coli: Escherichia coli, A. baumanni: K. pneumoniae: Klebsiella pneumoniae, Z: bacteriophage Z, P. stuartii: Providencia stuartii