- Univariate and multivariate analyses of clinicopathological factors linked to overall survival
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P-value | HR (95% CI) | P-value | |
| Change in NPS after NACR | ||||
| Elevated NPS group versus non-elevated NPS group | 1.631(1.061-2.507) | 0.026 | 1.868 (1.063-2.646) | 0.036 |
| Pre-NACR NPS | ||||
| ≥3 versus <3 | 0.940 (0.589-1.501) | 0.796 | ||
| Post-NACR NPS | ||||
| ≥3 versus <3 | 1.750 (1.140-2.687) | 0.010 | 1.072 (0.622-1.848) | 0.803 |
| Pre-NACR serum albumin (g/dL) | ||||
| <4 versus ≥4 | 1.088(0.658-1.797) | 0.742 | ||
| Pre-NACR total cholesterol (mg/dL) | ||||
| ≤180 versus >180 | 1.010(0.657-1.533) | 0.963 | ||
| Pre-NACR NLR | ||||
| >2.96 versus ≤2.96 | 0.806(0.505-1.287) | 0.366 | ||
| Pre-NACR LMR | ||||
| ≤4.44 versus <4.44 | 1.057(0.639-1.746) | 0.830 | ||
| Post-NACR serum albumin (g/dL) | ||||
| <4 versus ≥4 | 1.154(0.858-1.897) | 0.527 | ||
| Post-NACR total cholesterol (mg/dL) | ||||
| ≤180 versus >180 | 1.284(0.837-1.804) | 0.253 | ||
| Post-NACR NLR | ||||
| >2.96 versus ≤2.96 | 1.162(0.749-1.84) | 0.502 | ||
| Post-NACR LMR | ||||
| ≤4.44 versus <4.44 | 0.541(0.171-1.715) | 0.497 | ||
| Age (year) | ||||
| ≥60 versus <60 | 1.093 (0.700-1.708) | 0.696 | ||
| Gender | ||||
| Male versus female | 1.962 (0.947-4.067) | 0.07 | ||
| Tumor length | ||||
| >3 cm versus ≤3 cm | 1.861 (1.190-2.910) | 0.006 | 1.636 (1.013-2.641) | 0.044 |
| BMI (kg/m2) | ||||
| Before NAT (≤22 versus >22) | 1.483 (0.966-2.277) | 0.072 | ||
| Before surgery (≤22 versus >22) | 1.439 (0.938-2.208) | 0.096 | ||
| Tumor location | ||||
| Ut versus Mt/Lt | 1.034 (0.499-2.144) | 0.927 | ||
| ypTNM stage | ||||
| III-IV versus I-II | 4.127 (2.666-6.391) | <0.001 | 3.89 (2.475-6.115) | <0.001 |
| cTNM stage | ||||
| III-IV versus II | 1.010 (0.547-1.867) | 0.974 | ||
HR: hazard ratio, LMR: lymphocyte-to-monocyte ratio, NPS: naples prognostic score, NACR: neoadjuvant chemoradiotherapy, NLR: neutrophil-to-lymphocyte ratio, CI: confidence interval