- Between-group comparison of diffusion-weighted imaging, intravoxel incoherent motion, diffusion kurtosis imaging, and diffusion tensor imaging parameters with high inter-examiner reliability.
| Parameters | HVs | EHF | AHF | P-values (HVs vs. EHF) | P-values (EHF vs. AHF) |
|---|---|---|---|---|---|
| Diffusion-weighted imaging | |||||
| ADC (10-3 mm2/s) | 1.80±0.36 | 1.63±0.35 | 1.61±0.34 | 0.01* | 0.61 |
| Intravoxel incoherent motion | |||||
| D (10-3 mm2/s) | 1.00±0.28† | 0.94±0.25 | 0.91±0.25 | 0.31 | 0.96 |
| D* (10-3 mm2/s) | 92.65±70.95 | 114.89±67.76† | 83.62±40.62† | 0.02* | 0.04* |
| f (%) | 31.86±104.71 | 31.34±86.99 | 32.11±111.36 | 0.74 | 0.88 |
| DDC (10-3 mm2/s) | 2.91±2.78† | 1.98±1.36 | 3.21±2.51 | 0.30 | 0.02* |
| α (10-3 mm2/s) | 46.69±11.37 | 43.20±10.48 | 48.14±12.07 | 0.01* | 0.04* |
| Diffusion kurtosis imaging | |||||
| MK (10-3 mm2/s) | 0.77±0.11 | 0.78±0.12 | 0.79±0.20 | 0.48 | 0.56 |
| AK (10-3 mm2/s) | 0.74±0.12 | 0.75±0.14 | 0.76±0.18 | 0.69 | 0.92 |
| RK (10-3 mm2/s) | 0.74±0.13 | 0.74±0.15 | 0.77±0.21 | 0.57 | 0.97 |
| FAK (10-3 mm2/s) | 0.23±0.08 | 0.28±0.12 | 0.25±0.08 | 0.04* | 0.30 |
| Diffusion tensor imaging | |||||
| FA (10-3 mm2/s) | 0.23±0.05 | 0.24±0.07 | 0.24±0.08 | 0.35 | 0.39 |
| MD (10-3 mm2/s) | 2.01±0.39 | 1.91±0.40 | 1.96±0.39 | 0.37 | 0.51 |
| AD (10-3 mm2/s) | 1.39±0.23 | 1.37±0.25 | 1.36±0.23 | 0.74 | 0.93 |
| RD (10-3 mm2/s) | 1.11±0.19 | 1.08±0.17 | 1.10±0.20 | 0.43 | 0.54 |
Values are presented as mean ± standard deviation (SD).
HVs: healthy volunteers, EHF: early hepatic fibrosis, AHF: advanced hepatic fibrosis, ADC: apparent diffusion coefficient, D: real diffusion coefficient, D*: pseudo-diffusion coefficient, f: perfusion fraction, DDC: distributed diffusion coefficient, a: water-diffusion heterogeneity within voxels, MK: mean kurtosis, AK: axial kurtosis, RK: radial kurtosis, FAK: fractional anisotropy of kurtosis, FA: fractional anisotropy, MD: mean diffusivity, AD: axial diffusivity, RD: radial diffusivity