- Associations with hypothyroidism (n=49).
| Variable | True n (%) | False n (%) | P-value |
|---|---|---|---|
| Consanguinity between parents | 5 (45.45%) | 44 (17.74%) | 0.037 |
| Family history of endocrinopathies | 4 (57.14%) | 45 (17.86%) | 0.026 |
| Vitamin D deficiency | 18 (45%) | 31 (14.16%) | <0.001 |
| Dyslipidemia | 3 (75%) | 46 (18.04%) | 0.022 |
| Thyroid peroxidase antibodies | 2 (100%) | 47 (18.29%) | 0.035 |
| Obesity according to body mass index | 12 (37.5%) | 37 (16.3%) | 0.009 |
The percentages in the table represent the proportion of Down syndrome (DS) children within each condition who have hypothyroidism (True) compared to those without hypothyroidism (False). Each percentage is calculated within the corresponding row category. For example, 45% of DS children with vitamin D deficiency had hypothyroidism, while only 14.16% of those without vitamin D deficiency had hypothyroidism.