- Clinical and biochemical characteristics of patients with and without non-alcoholic fatty liver disease (N=1500).
| Parameters | Without NAFLD (n=765) | With NAFLD (n=735) | P-values |
|---|---|---|---|
| Age (years) | 34.54±11.23 | 55.55±12.21 | 0.001** |
| Gender (male/female) | 375/390 | 355/380 | - |
| FBG (mmol/L) | 4.9±1.31 | 6.5±1.41 | 0.001** |
| HbA1c (%) | 4.69±1.29 | 5.7±1.11 | <0.001** |
| LDL-C (mmol/L) | 2.22±0.31 | 2.22±0.40 | >0.05 |
| HDL-C (mmol/L) | 1.55±0.82 | 1.11±0.21 | <0.001** |
| Total cholesterol (mmol/L) | 4.78±1.23 | 5.88±1.41 | <0.001** |
| Triglycerides (mmol/L) | 1.2±1.13 | 2.5±1.10 | 0.001** |
| AIP = log (TG/HDL-C). | 0.11±0.10 | 0.3±0.11* | 0.002** |
| BMI (kg/m2) | 24.5±5.55 | 26.5±6.55† | <0.001** |
| hs-CRP(mg/l) | 2.5±1.32 | 3.9±1.16 | 0.001** |
| Albumin (g/dL) | 5.9±1.99 | 3.0±0.3 | 0.002** |
| Total protein (g/dL) | 7.5±1.87 | 5.3±1.2 | <0.001** |
| AST (IU/L) | 15.4±5.55 | 44.11±10.24 | 0.002** |
| ALT(IU/L) | 20.3±10.26 | 55.12±12.14 | <0.001** |
| ALP (IU/L) | 55.5±11.12 | 77±10.16 | 0.001** |
| AST: ALT ratio | 0.79±0.12 | 1.5±0.10 | >0.05 |
| Total bilirubin (mg/dL) | 0.69±0.12 | 0.69±0.11 | >0.05 |
| Serum creatinine(mg/dL) | 0.4±0.11 | 1.6±0.51 | <0.001** |
| Urine creatinine (mg/dL) | 65.5±10.11 | 300±20.51 | <0.001** |
| Urine albumin (mg/dL) | 1.8±0.16 | 35.5±7.16 | <0.001** |
| GFR (mL/min/1.73m2) | 138±10.21 | 70±8.11‡ | <0.001** |
| Urine albumin-to-creatinine ratio (mg/g) | 27.7±6.11 | 116.7±11.12§ | <0.001** |
| Creatine phosphokinase (mcg/L) | 15.5±5.21 | 60.43±10.11 | 0.002** |
Values are presented as mean ± standard deviation (SD). P-values obtained from the independent student t-test.
NAFLD: nonalcoholic fatty liver disease, FBG: fasting blood glucose, HbA1c: hemoglobin A1c, HDL-C: high density lipoprotein, LDL-C: low-density lipoprotein, hs-CRP: high-sensitivity C-reactive protein, AIP: atherogenic index of plasma, BMI: body mass index, AST: aspartate transaminase, ALT: alanine transaminase, ALP: alkaline phosphatase, GFR: glomerular filtration rate