Glycogenic hepatopathy, an underdiagnosed cause of relapsing hepatitis in uncontrolled type 1 diabetes mellitus

Ahmed A. Al Sarkhy, Zafar A. Zaidi, Amir M. Babiker


Glycogenic hepatopathy is a rare condition that causes significant hepatomegaly and elevated liver enzyme levels in uncontrolled type 1 diabetic patients. It develops due to excessive accumulation of glycogen in the hepatocytes. It is typically reversible with good glycemic control and rarely progresses to mild fibrosis, but not cirrhosis.


Saudi Med J 2017; Vol. 38 (1): 89-92

doi: 10.15537/smj.2017.1.15934

How to cite this article:

Al Sarkhy AA, Zaidi ZA, Babiker AM. Glycogenic hepatopathy, an underdiagnosed cause of relapsing hepatitis in uncontrolled type 1 diabetes mellitus. Saudi Med J. 2017 Jan;38(1):89-92. doi: 10.15537/smj.2017.1.15934.


Glycohen hepatopathy; Type 1 diabetes mellitus; relapsing hepatitis; underdiagnosed cause;

Full Text:



Torbenson M, Chen YY, Brunt E, Cummings OW, Gottfried M, Jakate S, et al. Glycogenic hepatopathy: an underrecognized hepatic complication of diabetes mellitus. Am J Surg Pathol 2006; 30: 508-513.

Mauriac P. Grosventre, hepatomegalie, troble de la croissance chez les enfants diabetiques: traits depuis plusieursannesparl’insuline. Gaz Hebl Sci Med Bordeaux. 1930; 26: 402-410.

Ikarashi Y, Kogiso T, Hashimoto E, Yamamoto K, Kodama K, Taniai M, et al. Four cases of type 1 diabetes mellitus showing sharp serum transaminase increases and hepatomegaly due to glycogenic hepatopathy. Hepatol Res 2016. [Epub ahead of print]

Tsujimoto T, Takano M, Nishiofuku M, Yoshiji H, Matsumura Y, Kuriyama S, et al. Rapid onset of glycogen storage hepatomegaly in a type-2 diabetic patient after a massive dose of long-acting insulin and large doses of glucose. Intern Med 2006; 45: 469-473.

Giordano S, Martocchia A, Toussan L, Stefanelli M, Pastore F, Devito A, et al. Diagnosis of hepatic glycogenosis in poorly controlled type 1 diabetes mellitus. World J of diabetes 2014; 5: 882-888.

Parmar N, Atiq M, Austin L, Miller RA, Smyrk T, Ahmed K. Glycogenic Hepatopathy: Thinking Outside the Box. Case Rep Gastroenterol 2015; 9: 221-226.

Fitzpatrick E, Cotoi C, Quaglia A, Sakellariou S, Ford-Adams ME, Hadzic N. Hepatopathy of Mauriac syndrome: a retrospective review from a tertiary liver centre. Arch Dis Child 2014; 99: 354-357.

Sweetser S, Kraichely RE. The bright liver of glycogenic hepatopathy. Hepatology 2010; 51: 711-712.

Murata F, Horie I, Ando T, Isomoto E, Hayashi H, Akazawa S, et al. A case of glycogenic hepatopathy developed in a patient with new-onset fulminant type 1 diabetes: the role of image modalities in diagnosing hepatic glycogen deposition including gradient-dual-echo MRI. Endocrine journal 2012; 59: 669-676.

Cha JH, Ra SH, Park YM, Ji YK, Lee JH, Park SY, et al. Three cases of glycogenic hepatopathy mimicking acute and relapsing hepatitis in type I diabetes mellitus. Clin Mol Hepatol 2013; 19: 421-425.


  • There are currently no refbacks.

Saudi Medical Journal is copyright under the Berne Convention and the International Copyright Convention.  Saudi Medical Journal is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3175. Print ISSN 0379-5284.