Neutrophil-to-lymphocyte ratio is effective prognostic indicator for post-amputation patients with critical limb ischemia

Qi Wang, Han Liu, Siqiao Sun, Zhihua Cheng, Yang Zhang, Xiwei Sun, Zhongying Wang, Shuai Wang


Objectives: To confirm whether neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are indicators for the prognosis of post-amputation patients with critical limb ischemia (CLI).


Methods: In this retrospective observational study a total 270 post-amputation patients with CLI were included between January 2010 and December 2014 in the First Hospital of Jilin University, Changchun, China. The neutrophil and lymphocyte counts were recorded before amputations. Neutrophil-to-lymphocyte ratio was calculated and NLR ≥8.08 was defined as elevated. Logistic regression analysis was conducted to test the prognostic value.


Results: According to the statistical analysis, it was indicated that NLR ≥8.08 (odds ratio [OR]: 26.228, 95% confidence interval [CI]: 5.801-118.583, p less than 0.001), PLR ≥237.14 (OR: 3.464, 95% CI: 1.289-9.308, p=0.014) and coronary heart disease (OR: 2.739, 95% CI: 1.060-7.082, p=0.038) were the independent prognostic indicators for the patients.


Conclusion: Neutrophil-to-lymphocyte ratio, PLR, and coronary heart disease are independent prognostic indicators for post-amputation patients with CLI.


Saudi Med J 2017; Vol. 38 (1): 24-29

doi: 10.15537/smj.2017.1.15936

How to cite this article:

Wang Q, Liu H, Sun S, Cheng Z, Zhang Y, Sun X, Wang Z, Wang S. Neutrophil-to-lymphocyte ratio is effective prognostic indicator for post-amputation patients with critical limb ischemia. Saudi Med J. 2017 Jan;38(1):24-29. doi: 10.15537/smj.2017.1.15936.


Neutrophil to lymphocyte ratio; critical limb ischemia; amputation; prognosis

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