Does weight loss affect the parameters that are metabolically related to cardiovascular diseases?

Ozlem Persil-Ozkan, Ece Yigit, Zerrin Yigit


Objectives: To assess the differences in the parameters that are metabolically related to cardiovascular diseases after weight loss in obese people with coronary artery diseases (CADs).

Methods: This study was conducted on 184 patients who were diagnosed with CADs in Istanbul University Cardiology Institute Hospital, Istanbul, Turkey. The levels of leptin, fibrinogen, homocysteine, high-sensitivity C-reactive protein (hs-CRP), triglycerides, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol (LDL-C), fasting blood glucose and insulin, glycated hemoglobin, and uric acid of the obese patients who were put on calorie restricted diet were evaluated retrospectively and compared before and after weight loss. For comparison, non-obese control patients were also studied. Student’s t-test and Chi-square test were used for the statistical analysis.


Results: Levels of homocysteine, glycated hemoglobin, and leptin were significantly higher in the obese patients than in the non-obese patients. Diabetic obese patients with CADs lost (11.1%) and non-diabetic obese patients with CADs lost (10.5%) of their body weight in 6 months. The levels of cholesterol, LDL-C, and fibrinogen were significantly improved in both groups.


Conclusion: The obese patients lost weight after being on calorie-restricted diets and showed significant improvement in the levels of cholesterol, LDL-C, fibrinogen. There was no significant difference in the levels of homocysteine, hs-CRP, and leptin before and after weight loss in both diabetic and non-diabetic obese patients.


Saudi Med J 2019; Vol. 40 (4): 347-352
doi: 10.15537/smj.2019.4.24007

How to cite this article:
Persil-Ozkan O, Yigit E, Yigit Z. Does weight loss affect the parameters that are metabolically related to cardiovascular diseases? Saudi Med J. 2019 Apr;40(4):347-352. doi: 10.15537/smj.2019.4.24007.



endothelial dysfunction; obesity; weight loss; cardiovascular diseases

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Yu E, Malik VS, Hu FB. Reprint of: Cardiovascular Disease Prevention by Diet Modification: JACC Health Promotion Series. J Am Coll Cardiol 2018; 72: 2951-2963.

Sun HJ, Hou B, Wang X, Zhu XX, Li KX, Qiu LY. Endothelial dysfunction and cardiometabolic diseases: Role of long non-coding RNAs. Life Sci 2016; 167: 6-11.

Bruyndonckx L, Hoymans VY, De Guchtenaere A, Van Helvoirt M, Van Craenenbroeck EM, Frederix G, et al. Diet, exercise, and endothelial function in obese adolescents. Pediatrics 2015; 135: e653-e661.

Avan A, Tavakoly Sany SB, Ghayour-Mobarhan M, Rahimi HR, Tajfard M, Ferns G. Serum C-reactive protein in the prediction of cardiovascular diseases: Overview of the latest clinical studies and public health practice. J Cell Physiol 2018; 233: 8508-8525.

Lovren F, Teoh H, Verma S. Obesity and atherosclerosis: mechanistic insights. Can J Cardiol 2015; 31: 177-183.

Oikonomou EK, Antoniades C. The role of adipose tissue in cardiovascular health and disease. Nat Rev Cardiol 2019; 16: 83-99.

Katsiki N, Mikhailidis DP, Banach M. Leptin, cardiovascular diseases and type 2 diabetes mellitus. Acta Pharmacol Sin 2018; 39: 1176-1188.

Huang CJ, McAllister MJ, Slusher AL, Webb HE, Mock JT, Acevedo EO. Obesity-Related Oxidative Stress: the Impact of Physical Activity and Diet Manipulation. Sports Med Open 2015; 1: 32.

Lacey B, Herrington WG, Preiss D, Lewington S, Armitage J. The Role of Emerging Risk Factors in Cardiovascular Outcomes. Curr Atheroscler Rep 2017; 19: 28.

Escárcega RO, Lipinski MJ, García-Carrasco M, Mendoza-Pinto C, Galvez-Romero JL, Cervera R. Inflammation and atherosclerosis: Cardiovascular evaluation in patients with autoimmune diseases. Autoimmun Rev 2018; 17: 703-708.

Sreckovic B, Sreckovic VD, Soldatovic I, Colak E, Sumarac-Dumanovic M, Janeski H, et al. Homocysteine is a marker for metabolic syndrome and atherosclerosis. Diabetes Metab Syndr 2017; 11: 179-182.

Farias G. Good weight loss responders and poor weight loss responders after Roux-en-Y gastric bypass: clinical and nutritional profiles. Nutr Hosp 2016; 33: 1108-1115.

Golbidi S, Daiber A, Korac B, Li H, Essop MF, Laher I. Health Benefits of Fasting and Caloric Restriction. Curr Diab Rep 2017; 17: 123.

World Health Organization. Global database on body mass index; 2004. Available from:

De Rosa S, Arcidiacono B, Chiefari E, Brunetti A, Indolfi C, Foti DP. Type 2 Diabetes Mellitus and Cardiovascular Disease: Genetic and Epigenetic Links. Front Endocrinol (Lausanne) 2018; 9: 2.

King RJ, Ajjan RA. Vascular risk in obesity: Facts, misconceptions and the unknown. Diab Vasc Dis Res 2017; 14: 2-13.

Ho TP, Zhao X, Courville AB, Linderman JD, Smith S, Sebring N, et al. Effects of a 12-month moderate weight loss intervention on insulin sensitivity and inflammation status in nondiabetic overweight and obese subjects. Horm Metab Res 2015; 47: 289-296.

Gutiérrez L, García JR, Rincón Mde J, Ceballos GM, Olivares IM. [Effect of a hypocaloric diet in the oxidative stress in obese subjects without prescription of exercise and antioxidants]. Med Clin (Barc) 2015; 145: 1-6. [Spanish]

Razavi Zade M, Telkabadi MH, Bahmani F, Salehi B, Farshbaf S, Asemi Z. The effects of DASH diet on weight loss and metabolic status in adults with non-alcoholic fatty liver disease: a randomized clinical trial. Liver Int 2016; 36: 563-571.

Aboutaleb N, Zarrati M, Cheshmazar E, Shoormasti RS, Razmpoosh E, Nasirinezhad F. Association between the circulating leptin levels and the biomarkers of oxidative stress and inflammation among Iranian overweight and obese adults. Med J Islam Repub Iran 2017; 31: 81.

Korybalska K, Luczak J, Swora-Cwynar E, Kanikowska A, Czepulis N, Kanikowska D, et al. Weight loss-dependent and -independent effects of moderate calorie restriction on endothelial cell markers in obesity. J Physiol Pharmacol 2017; 68: 597-608.

Netto BD, Bettini SC, Clemente AP, Ferreira JP, Boritza K, Souza Sde F, et al. Roux-en-Y gastric bypass decreases pro-inflammatory and thrombotic biomarkers in individuals with extreme obesity. Obes Surg 2015; 25: 1010-1018.

Aziz CB, Omar N, Abdullah WZ, Jalil RA, Nik WS, Zakaria R. Reduced fibrinogen, fibrinolytic biomarkers, and physical parameters after a weight-loss program in obese subjects. N Am J Med Sci 2014; 6: 377-382.

Yang B, Fan S, Zhi X, He J, Ma P, Yu L, et al. Interactions of homocysteine and conventional predisposing factors on hypertension in Chinese adults. J Clin Hypertens (Greenwich) 2017; 19: 1162-1170.

Al-Bayyari N, Hamadneh J, Hailat R, Hamadneh S. Total homocysteine is positively correlated with body mass index, waist-to-hip ratio, and fat mass among overweight reproductive women: A cross-sectional study. Nutr Res 2017; 48: 9-15.

Yilmaz VT, Çoban E, Avci AB, Yilmaz F, Çetinkaya R. Levels of plasma homocysteine in obese women subjects homocysteine and obesity. Turkish Nephrol Dial Transplant J 2014; 23: 91-94.

Picca A, Pesce V, Lezza AMS. Does eating less make you live longer and better? An update on calorie restriction. Clin Interv Aging 2017; 12: 1887-1902.

Lambert EA, Sari CI, Eikelis N, Phillips SE, Grima M, Straznicky NE, et al. Effects of Moxonidine and Low-Calorie Diet: Cardiometabolic Benefits from Combination of Both Therapies. Obesity (Silver Spring) 2017; 25: 1894-1902.


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