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Benzylamides fromSalvadora persica

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Abstract

A phytochemical investigation of stems fromSalvadora persica resulted in the first isolation of four benzylamides from a natural source. The isolated compounds were identified as butanediamide,N 1,N 4-bis(phenylmethyl)-2(S)-hydroxy-butanediamide (1),N-benzyl-2-phenylacetamide (2),N-benzylbenzamide (3) and benzlurea (4). The structure elucidation was accomplished using spectroscopic methods, especially 2D NMR and HREIMS. Compound2 revealed a significant inhibitory effect on human collagen-induced platelet aggregation, and a moderate antibacterial activity againstEscherichia coli.

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Correspondence to Ashraf Taha Khalil.

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Khalil, A.T. Benzylamides fromSalvadora persica . Arch Pharm Res 29, 952–956 (2006). https://doi.org/10.1007/BF02969277

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  • DOI: https://doi.org/10.1007/BF02969277

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