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Peritumoural, but not intratumoural, lymphatic vessel density and invasion correlate with colorectal carcinoma poor-outcome markers

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Abstract

To evaluate whether lymphatic vessel density (LVD) and lymphatic vessel invasion (LVI) are useful markers of worse outcome in colorectal carcinoma and if LVD and LVI correlate to the classical clinical-pathological parameters, we analysed 120 cases of colorectal carcinomas selected from the files of Division of Pathology, Hospital das Clinicas, São Paulo University, Brazil. Assessment of LVD and LVI was performed by immunohistochemical detection of lymphatic vessels, using the monoclonal antibody D2-40. Higher LVD was found in the intratumoural area, when comparing with normal and peritumoural areas (p < 0.001). However, peritumoural LVD, but not intratumoural, correlated with both colonic-wall-invasion depth (p = 0.037) and liver metastasis (p = 0.012). Remarkably, LVI was found associated with local invasion (p = 0.016), nodal metastasis (p = 0.022) and hepatic metastasis (p < 0.001). Peritumoural LVD and LVI are directly related to histopathological variables indicative of poor outcome such as lymph-node status and liver metastasis.

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Conflict of interest statement

We declare that we have no conflict of interest.

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Authors and Affiliations

  1. Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, 4710-057, Braga, Portugal

    Adhemar Longatto-Filho, Céline Pinheiro, Luísa Ferreira & Fátima Baltazar

  2. Instituto Adolfo Lutz, São Paulo, Brazil

    Adhemar Longatto-Filho

  3. LIM14-Department of Pathology, São Paulo University School of Medicine, São Paulo, Brazil

    Cristovam Scapulatempo & Venancio A. F. Alves

  4. IPATIMUP, Porto, Portugal

    Fernando Schmitt

  5. Medical Faculty of the University of Porto, Porto, Portugal

    Fernando Schmitt

Authors
  1. Adhemar Longatto-Filho
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  2. Céline Pinheiro
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  3. Luísa Ferreira
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  4. Cristovam Scapulatempo
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  5. Venancio A. F. Alves
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  6. Fátima Baltazar
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  7. Fernando Schmitt
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Correspondence to Adhemar Longatto-Filho.

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Longatto-Filho, A., Pinheiro, C., Ferreira, L. et al. Peritumoural, but not intratumoural, lymphatic vessel density and invasion correlate with colorectal carcinoma poor-outcome markers. Virchows Arch 452, 133–138 (2008). https://doi.org/10.1007/s00428-007-0550-0

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  • DOI: https://doi.org/10.1007/s00428-007-0550-0

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