Abstract
Over an 8-year period (January 1996 to December 2003), a total of 171 patients below the age of 15 years were diagnosed with chronic renal failure. The mean incidence rate of CRF in Kuwaiti children was found to be 38.2 per million children per year, with a peak incidence of 55 per million children per year. While the mean age at diagnosis was 33±12 months (range: 1 month to 15 years), the male:female ratio was 2.7:1. Etiological factors for chronic renal failure included congenital urological malformation (61.9%), chronic glomerulopathies (5.2%), hereditary nephropathies (21%), multi-system disease (0.5%), chronic pyelonephritis (without VUR) (4.6%), tumors (0.6%), ischemic renal disease (1.1%) and unknown etiology (1.7%). Thirty percent of patients reached end-stage renal disease within a mean of 18 months following diagnosis. The overall mortality before reaching ESRD was reported to be 4%. Kuwait has one of the highest incidence and prevalence rates of CRF in children. It is likely that genetic and hereditary factors are the cause of these high rates.
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References
PACI (2004) Directory of population and labor forces, 1995 to 2003. Public Authority for Civil Information (PACI), Ministry of Planning, Kuwait
Madani K, Otoukesh H, Rastegar A, Van Why S (2001) Chronic renal failure in Iranian children. Pediatr Nephrol 16:140144
Lewis M (1999) Report of the Pediatric Renal Registry. In: Ansel D, Feest T (eds) UK Renal Registry Report 1999. UK Renal Registry, Bristol, Ch 15
British Association for Paediatric Nephrology (1995) Report of a Working Party of the British Association for Paediatric Nephrology: the provision of services in the United Kingdom for children and adolescents with renal disease. British Association for Paediatric Nephrology, London
Stablien DM, Ho M (2001) North American Pediatric Renal Transplant Cooperative Study 2001 Annual Report. EMMES Corporation, Potomac, MD
Aldress A, Kurpad R, Al-Sabban EA, Ikram H, Abu-Aisha H (1991) Chronic renal failure in children in 36 Saudi Arabian hospitals. Saudi Kidney Dis Transplant Bull 2:134–138
Foreman JW, Chan JCM (1988) Chronic renal failure in infants and children. J Pediatr 113:793–800
Potter DE, Holliday MA, Piel CF, et al (1980) Treatment of end stage renal disease in children: a 15 year experience. Kidney Int 18:103
Esbjörner E, Aroson S, Berg U, Jodal U, Linne T (1990) Children with chronic renal failure in Sweden 1978–1985. Pediatr Nephrol 4:249–252
Esbjörner E, Berg U, Hansson S (1997) Epidemiology of chronic renal failure in children: a report from Sweden 1986–1994. Pediatr Nephrol 11:438–442
Stoll C, Alembik Y, Dott B, Feingold J (1994) Parental consanguinity as a cause of increased incidence of birth defects in a study of 131,760 consecutive births. Am J Med Genet 49:114–117
Al-Awadi SA, Moussa MA, Naguib KK, et al (1985) Consanguinity among the Kuwaiti population. Clin Genet 27:483–486
Al-Gazali LI, Dawodu AH, Sabarinathan K, Varghese M (1995) The profile of major congenital abnormalities in the United Arab Emirates population. J Med Genet 32:7–13
Radovanovic Z, Shah N, Behbehani J (1999) Prevalence and social correlates of consanguinity in Kuwait. Ann Saudi Med 19:206–210
Berry CA, Chantler C (1986) Urological malformation and disease. Br Med Bull 42:181–186
Helin I, Winberg J (1980) Chronic renal failure in Swedish children. Acta Paediatr Scand 69:607–611
Mattoo TK, Al-Mahalhal S, Al-Sowailam AM, Al-Harbi M, Mahmood MA (1990) Chronic renal failure in children in Saudi Arabia. Ann Saudi Med 10:496–499
Anonymous (1998) Pediatric end-stage renal disease. United States Renal Data System. Am J Kidney Dis 32:S98–108
Anonymous (1999) Pediatric end-stage renal disease. Am J Kidney Dis 34:102–113
Deleau J, Andre JL, Briancon S, Musse JP (1994) Chronic renal failure in children: an epidemiological survey in Lorraine (France) 1975–1990. Pediatr Nephrol 8:472–476
Boyer M, Brunner F, Brynger H, Fassbinder W, Guillou PJ, Oules R, Rizzoni G, Selwood NH, Wing AJ, Challah S, Dykes SR (1986). Demography of dialysis and transplantation in children in Europe; 1984. Nephrol Dial Transplant 1:9–15
Schárer K, Reiss U, Mehls O, Gretz N, Möhring K, Müller-Wiefel DE, Wingen A (1993) Changing pattern of chronic renal failure and renal replacement therapy in children and adolescents: a 20-year single centre study. Eur J Pediatr 152:166–171
Al-Eisa A, Al-Hunayyan A, Gupta R (2002) Pediatric urolithiasis in Kuwait. Int Urol Nephrol 33:3–6
Al-Eisa A, Samhan M, Naseef M (2004) End-stage renal disease in Kuwaiti children: an eight-year experience. Transplant Proc 36:1788–1791
Al-Eisa A, Al-Hajeri M (2001) Hemolytic uremic syndrome in Kuwaiti Arab children. Pediatr Nephrol 16:1093–1098
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Al-Eisa, A., Naseef, M., Al-Hamad, N. et al. Chronic renal failure in Kuwaiti children: an eight-year experience. Pediatr Nephrol 20, 1781–1785 (2005). https://doi.org/10.1007/s00467-005-2000-z
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DOI: https://doi.org/10.1007/s00467-005-2000-z