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Clinical features and outcomes of Staphylococcus aureus infections in non-neutropenic cancer patients

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Abstract

Goal of work

This study was performed to evaluate the clinical features and outcomes of Staphylococcus aureus infection in non-neutropenic cancer patients.

Materials and methods

From the database of a surveillance study for S. aureus infections, the data regarding S. aureus infections in non-neutropenic cancer patients were analyzed.

Main results

Of 649 non-neutropenic cancer patients with S. aureus infections, 156 (24.0%) had a central venous catheter and 176 (27.1%) had an indwelling urinary catheter. The prevalence of methicillin-resistant S. aureus (MRSA) infections was 54.7% (355 out of 649). As for types of infection, skin and soft tissue infections were the most common (n = 173, 26.7%), followed by pneumonia (n = 165, 25.4%) and primary bacteremia (n = 91; 14.0%). Overall, the 30-day mortality rate was 28.2% (124 out of 440), 34.1% (73 out of 214) in MRSA group, and 22.6% (51 out of 226) in methicillin-sensitive S. aureus group (P = 0.007). When outcomes according to the types of infection were evaluated, the mortality rates were 49.5% (53 out of 107) for pneumonia and 41.2% (49 out of 119) for bacteremia. Multivariate analysis showed that pneumonia, concomitant bacteremia, comorbid liver disease, and intubated state with ICU care were independent risk factors associated with 30-day mortality.

Conclusion

Our study demonstrated that S. aureus infections in cancer patients are serious clinical conditions with high mortality rates, even in non-neutropenic patients.

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References

  1. Berghmans T, Sculier JP, Klastersky J (2003) A prospective study of infections in lung cancer patients admitted to the hospital. Chest 124:114–120

    Article  PubMed  Google Scholar 

  2. Inagaki J, Rodriguez V, Bodey GP (1974) Proceedings: causes of death in cancer patients. Cancer 33:568–573

    Article  PubMed  CAS  Google Scholar 

  3. Gopal AK, Fowler VG Jr, Shah M, Gesty-Palmer D, Marr KA, McClelland RS, Kong LK, Gottlieb GS, Lanclos K, Li J, Sexton DJ, Corey GR (2000) Prospective analysis of Staphylococcus aureus bacteremia in nonneutropenic adults with malignancy. J Clin Oncol 18:1110–1115

    PubMed  CAS  Google Scholar 

  4. Stryjewski ME, Kanafani ZA, Chu VH, Pappas PA, Harding T, Drew LA, Benjamin DK Jr, Reller LB, Lee BA, Corey GR, Fowler VG Jr (2009) Staphylococcus aureus bacteremia among patients with health care-associated fever. Am J Med 122(281–289):e282

    Google Scholar 

  5. Laupland KB, Ross T, Gregson DB (2008) Staphylococcus aureus bloodstream infections: risk factors, outcomes, and the influence of methicillin resistance in Calgary, Canada, 2000–2006. J Infect Dis 198:336–343

    Article  PubMed  Google Scholar 

  6. Soriano A, Martinez JA, Mensa J, Marco F, Almela M, Moreno-Martinez A, Sanchez F, Munoz I, Jimenez de Anta MT, Soriano E (2000) Pathogenic significance of methicillin resistance for patients with Staphylococcus aureus bacteremia. Clin Infect Dis 30:368–373

    Article  PubMed  CAS  Google Scholar 

  7. Marty L, Flahault A, Suarez B, Caillon J, Hill C, Andremont A (1993) Resistance to methicillin and virulence of Staphylococcus aureus strains in bacteriemic cancer patients. Intensive Care Med 19:285–289

    Article  PubMed  CAS  Google Scholar 

  8. Sotman SB, Schimpff SC, Young VM (1980) Staphylococcus aureus bacteremia in patients with acute leukemia. Am J Med 69:814–818

    Article  PubMed  CAS  Google Scholar 

  9. Velasco E, Byington R, Martins CA, Schirmer M, Dias LM, Goncalves VM (2006) Comparative study of clinical characteristics of neutropenic and non-neutropenic adult cancer patients with bloodstream infections. Eur J Clin Microbiol Infect Dis 25:1–7

    Article  PubMed  CAS  Google Scholar 

  10. Sipsas NV, Bodey GP, Kontoyiannis DP (2005) Perspectives for the management of febrile neutropenic patients with cancer in the 21st century. Cancer 103:1103–1113

    Article  PubMed  Google Scholar 

  11. Song JH, Hsueh PR, Ko KS, Kang CI, Chung DR (2008) Nosocomial origin of community-associated methicillin-resistant Staphylococcus aureus in Asian countries: an ANSORP surveillance study. In: 48th annual ICAAC/IDSA 46th annual meeting, Washington, 25–28 October 2008, p 152

  12. Kang CI, Song JH, Chung DR, Peck KR, Ko KS, Yeom JS, Kim SW, Chang HH, Kim YS, Jung SI, Son JS, Hsueh PR, So TM, Lalitha MK, Yang Y, Huang SG, Wang H, Lu Q, Carlos CC, Perera JA, Chiu CH, Liu JW, Chongthaleong A, Thamlikitkul V, Van Pham H (2010) Clinical impact of methicillin resistance on outcome of patients with Staphylococcus aureus infection: a stratified analysis according to underlying diseases and sites of infection in a large prospective cohort. J Infect 61:299–306

    Article  PubMed  Google Scholar 

  13. Laupland KB, Church DL, Mucenski M, Sutherland LR, Davies HD (2003) Population-based study of the epidemiology of and the risk factors for invasive Staphylococcus aureus infections. J Infect Dis 187:1452–1459

    Article  PubMed  Google Scholar 

  14. Friedman ND, Kaye KS, Stout JE, McGarry SA, Trivette SL, Briggs JP, Lamm W, Clark C, MacFarquhar J, Walton AL, Reller LB, Sexton DJ (2002) Health care-associated bloodstream infections in adults: a reason to change the accepted definition of community-acquired infections. Ann Intern Med 137:791–797

    PubMed  Google Scholar 

  15. Cheong HS, Kang CI, Wi YM, Kim ES, Lee JS, Ko KS, Chung DR, Lee NY, Song JH, Peck KR (2008) Clinical significance and predictors of community-onset Pseudomonas aeruginosa bacteremia. Am J Med 121:709–714

    Article  PubMed  Google Scholar 

  16. Kim SH, Park WB, Lee KD, Kang CI, Kim HB, Oh MD, Kim EC, Choe KW (2003) Outcome of Staphylococcus aureus bacteremia in patients with eradicable foci versus noneradicable foci. Clin Infect Dis 37:794–799

    Article  PubMed  Google Scholar 

  17. Kang CI, Song JH, Ko KS, Chung DR, Peck KR (2010) Clinical significance of Staphylococcus aureus infection in patients with chronic liver diseases. Liver Int 30:1333–1338

    Article  PubMed  Google Scholar 

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Acknowledgments

The authors would like to thank all investigators of the ANSORP study group who participated in this study. This study was financially supported by the Asia Pacific Foundation for Infectious Diseases (Seoul, South Korea).

Potential conflicts of interest

No conflicts for all authors.

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Authors and Affiliations

  1. Division of Infectious Diseases, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Gangnam-gu, Seoul, 135-710, Republic of Korea

    Cheol-In Kang, Jae-Hoon Song, Doo Ryeon Chung & Kyong Ran Peck

  2. Department of Molecular Cell Biology, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea

    Kwan Soo Ko

  3. Asia Pacific Foundation for Infectious Diseases, Seoul, Republic of Korea

    Jae-Hoon Song

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  1. Cheol-In Kang
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  2. Jae-Hoon Song
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  5. Kyong Ran Peck
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Asian Network for Surveillance of Resistant Pathogens (ANSORP) Study Group

Corresponding author

Correspondence to Jae-Hoon Song.

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Kang, CI., Song, JH., Ko, K.S. et al. Clinical features and outcomes of Staphylococcus aureus infections in non-neutropenic cancer patients. Support Care Cancer 20, 483–488 (2012). https://doi.org/10.1007/s00520-011-1100-5

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  • DOI: https://doi.org/10.1007/s00520-011-1100-5

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