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Leisure Time Physical Activity and the Risk of Pre-eclampsia: A Systematic Review

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An Erratum to this article was published on 16 July 2014

Abstract

Today, pre-eclampsia (PE) is one of the leading causes of maternal and perinatal morbidity and mortality. It has been proposed that leisure time physical activity (LTPA) is associated with a decreased risk of PE. The objective of this study was to perform a systematic literature review examining the association between LTPA before and/or during pregnancy and the risk of PE. A systematic search of the EMBASE and PUBMED databases from inception to November 17, 2011 was conducted by two independent reviewers. Only studies describing the association between the intensity or amount of LTPA before and/or during pregnancy and the risk of PE were included. A narrative synthesis of the results was undertaken following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A quality assessment was performed using the Newcastle Ottawa Scale. Eleven studies were included. None of the studies found light- or moderate-intensity LTPA to be associated with PE. Three studies reported that vigorous-intensity LTPA before and/or during pregnancy may reduce the risk of PE. One study reported a reduced risk among women who participated in LTPA at least 25 times per month or more than 4 h per week. However, one study found an elevated risk of severe PE with high amounts of LTPA, defined as 4.5 h per week or more. Results are mixed, but high intensity LTPA before and/or during pregnancy or more than 4 h per week of LTPA may reduce the risk of PE. However, an urgent need remains for high-quality studies including different ethnicities to further explore this relationship.

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References

  1. Sibai, B., Dekker, G., & Kupferminc, M. (2005). Pre-eclampsia. Lancet, 365(9461), 785–799.

    Article  PubMed  Google Scholar 

  2. Hernández-Díaz, S., Toh, S., & Cnattingius, S. (2009). Risk of pre-eclampsia in first and subsequent pregnancies: Prospective cohort study. British Medical Journal, 338, b2255.

    Article  PubMed Central  PubMed  Google Scholar 

  3. Meher, S., & Duley, L. (2006). Exercise or other physical activity for preventing pre-eclampsia and its complications. Cochrane Database Systematic Review, 2, CD005942.

    Google Scholar 

  4. Smith, G. C., Pell, J. P., & Walsh, D. (2001). Pregnancy complications and maternal risk of ischaemic heart disease: A retrospective cohort study of 129,290 births. Lancet, 357(9273), 2002–2006.

    Article  CAS  PubMed  Google Scholar 

  5. Jónsdóttir, L. S., Arngrímsson, R., Geirsson, R. T., Sigvaldason, H., & Sigfússon, N. (1995). Death rates from ischemic heart disease in women with a history of hypertension in pregnancy. Acta Obstetricia et Gynecologica Scandinavica, 74(10), 772–776.

    Article  PubMed  Google Scholar 

  6. Arnadottir, G. A., Geirsson, R. T., Arngrimsson, R., Jonsdottir, L. S., & Olafsson, O. (2005). Cardiovascular death in women who had hypertension in pregnancy: A case-control study. British Journal of Obstetrics, 112(3), 286–292.

    Article  Google Scholar 

  7. Wikström, A.-K., Haglund, B., Olovsson, M., & Lindeberg, S. N. (2005). The risk of maternal ischaemic heart disease after gestational hypertensive disease. British Journal of Obstetrics, 112(11), 1486–1491.

    Article  Google Scholar 

  8. Brown, D. W., Dueker, N., Jamieson, D. J., Cole, J. W., Wozniak, M. A., Stern, B. J., et al. (2006). Preeclampsia and the risk of ischemic stroke among young women: Results from the stroke prevention in young women study. Stroke, 37(4), 1055–1059.

    Article  PubMed  Google Scholar 

  9. Salvador-Moysén, J., Martínez-López, Y., Ramírez-Aranda, J. M., Aguilar-Durán, M., Terrones-González, A. (2012). Genesis of preeclampsia: An epidemiological approach. ISRN Obstetrics and Gynecology.

  10. Bodnar, L. M., Catov, J. M., Klebanoff, M. A., Ness, R. B., & Roberts, J. M. (2007). Prepregnancy body mass index and the occurrence of severe hypertensive disorders of pregnancy. Epidemiology, 18(2), 234–239.

    Article  PubMed  Google Scholar 

  11. Eskenazi, B., Fenster, L., & Sidney, S. (1991). A multivariate analysis of risk factors for preeclampsia. The Journal of the American Medical Association, 266(2), 237–241.

    Article  CAS  Google Scholar 

  12. O’Brien, T. E., Ray, J. G., & Chan, W.-S. (2003). Maternal body mass index and the risk of preeclampsia: A systematic overview. Epidemiology, 14(3), 368–374.

    PubMed  Google Scholar 

  13. Dalmáz, C. A., dos Santos, K. G., Botton, M. R., & Roisenberg, I. (2011). Risk factors for hypertensive disorders of pregnancy in southern Brazil. Revista Da Associacao Medica Brasileira, 57(6), 692–696.

    Article  PubMed  Google Scholar 

  14. Kashanian, M., Baradaran, H. R., Bahasadri, S., & Alimohammadi, R. (2011). Risk factors for pre-eclampsia: A study in Tehran, Iran. Archives of Iranian Medicine, 14(6), 412–415.

    PubMed  Google Scholar 

  15. Trogstad, L. I., Eskild, A., Magnus, P., Samuelsen, S. O., & Nesheim, B. I. (2001). Changing paternity and time since last pregnancy; the impact on pre-eclampsia risk. A study of 547 238 women with and without previous pre-eclampsia. International Journal of Epidemiology, 30(6), 1317–1322.

    Article  CAS  PubMed  Google Scholar 

  16. Kyrou, D., Kolibianakis, E. M., Devroey, P., & Fatemi, H. M. (2010). Is the use of donor sperm associated with a higher incidence of preeclampsia in women who achieve pregnancy after intrauterine insemination? Fertility and Sterility, 93(4), 1124–1127.

    Article  PubMed  Google Scholar 

  17. Kaaja, R. J., & Greer, I. A. (2005). Manifestations of chronic disease during pregnancy. The Journal of the American Medical Association, 294(21), 2751–2757.

    Article  CAS  Google Scholar 

  18. Pedersen, B. K., & Saltin, B. (2006). Evidence for prescribing exercise as therapy in chronic disease. Scandinavian Journal of Medicine and Science in Sports, 16(Suppl 1), 3–63.

    Article  PubMed  Google Scholar 

  19. Moher, D., Liberati, A., Tetzlaff, J., & Altman, D. G. (2009). Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. Journal of Clinical Epidemiology, 62(10), 1006–1012.

    Article  PubMed  Google Scholar 

  20. Bouchard, C., Malina, R. M., Pérusse, L. (1997). Genetics of fitness and physical performance. Human Kinetics, 1, 89–97.

    Google Scholar 

  21. Wells, G. A. et al. (2012). The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses [Internet]. Department of Epidemiology and Commuunity Medicine, Ottawa. Hentet fra: http://www.ohri.ca/programs/clinical_epidemiology/oxford.htm.

  22. Marcoux, S., Brisson, J., & Fabia, J. (1989). The effect of leisure time physical activity on the risk of pre-eclampsia and gestational hypertension. Journal of Epidemiology and Community Health, 43(2), 147–152.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  23. Rudra, C. B., Sorensen, T. K., Luthy, D. A., & Williams, M. A. (2008). A prospective analysis of recreational physical activity and preeclampsia risk. Medicine and Science in Sports and Exercise, 40(9), 1581–1588.

    Article  PubMed  Google Scholar 

  24. Østerdal, M. L., Strøm, M., Klemmensen, A. K., Knudsen, V. K., Juhl, M., Halldorsson, T. I., et al. (2009). Does leisure time physical activity in early pregnancy protect against pre-eclampsia? Prospective cohort in Danish women. British Journal of Obstetrics, 116(1), 98–107.

    Article  Google Scholar 

  25. Vollebregt, K. C., Wolf, H., Boer, K., Van der Wal, M. F., Vrijkotte, T. G. M., & Bonsel, G. J. (2010). Does physical activity in leisure time early in pregnancy reduce the incidence of preeclampsia or gestational hypertension? Acta Obstetricia et Gynecologica Scandinavica, 89(2), 261–267.

    Article  PubMed  Google Scholar 

  26. Rudra, C. B., Williams, M. A., Lee, I.-M., Miller, R. S., & Sorensen, T. K. (2005). Perceived exertion during prepregnancy physical activity and preeclampsia risk. Medicine and Science in Sports and Exercise, 37(11), 1836–1841.

    Article  PubMed  Google Scholar 

  27. Fortner, R. T., Pekow, P. S., Whitcomb, B. W., Sievert, L. L., Markenson, G., & Chasan-Taber, L. (2011). Physical activity and hypertensive disorders of pregnancy among Hispanic women. Medicine and Science in Sports and Exercise, 43(4), 639–646.

    Article  PubMed  Google Scholar 

  28. Tyldum, E. V., Romundstad, P. R., & Slørdahl, S. A. (2010). Pre-pregnancy physical activity and preeclampsia risk: A prospective population-based cohort study. Acta Obstetricia et Gynecologica Scandinavica, 89(3), 315–320.

    Article  PubMed  Google Scholar 

  29. Magnus, P., Trogstad, L., Owe, K. M., Olsen, S. F., & Nystad, W. (2008). Recreational physical activity and the risk of preeclampsia: A prospective cohort of Norwegian women. American Journal of Epidemiology, 168(8), 952–957.

    Article  PubMed Central  PubMed  Google Scholar 

  30. Sorensen, T. K., Williams, M. A., Lee, I.-M., Dashow, E. E., Thompson, M. L., & Luthy, D. A. (2003). Recreational physical activity during pregnancy and risk of preeclampsia. Hypertension, 41(6), 1273–1280.

    Article  CAS  PubMed  Google Scholar 

  31. Hegaard, H. K., Ottesen, B., Hedegaard, M., Petersson, K., Henriksen, T. B., Damm, P., et al. (2010). The association between leisure time physical activity in the year before pregnancy and pre-eclampsia. Journal of Obstetrics and Gynaecology, 30(1), 21–24.

    Article  CAS  PubMed  Google Scholar 

  32. Saftlas, A. F., Logsden-Sackett, N., Wang, W., Woolson, R., & Bracken, M. B. (2004). Work, leisure-time physical activity, and risk of preeclampsia and gestational hypertension. American Journal of Epidemiology, 160(8), 758–765.

    Article  PubMed  Google Scholar 

  33. Klemmensen, A. K., Olsen, S. F., Osterdal, M. L., & Tabor, A. (2007). Validity of preeclampsia-related diagnoses recorded in a national hospital registry and in a postpartum interview of the women. American Journal of Epidemiology, 166(2), 117–124.

    Article  PubMed  Google Scholar 

  34. ACOG Committee opinion. (2002). Number 267, January 2002: Exercise during pregnancy and the postpartum period. Obstetrics and Gynecology, 99(1), 171–173.

    Article  Google Scholar 

  35. Sallis, J. F., & Saelens, B. E. (2000). Assessment of physical activity by self-report: Status, limitations, and future directions. Research Quarterly for Exercise and Sport, 71(2 Suppl), S1–S14.

    CAS  PubMed  Google Scholar 

  36. Swain, D. P., & Franklin, B. A. (2006). Comparison of cardioprotective benefits of vigorous versus moderate intensity aerobic exercise. American Journal of Cardiology, 97(1), 141–147.

    Article  PubMed  Google Scholar 

  37. Bhattacharya, S., Campbell, D. M., Liston, W. A., & Bhattacharya, S. (2007). Effect of Body Mass Index on pregnancy outcomes in nulliparous women delivering singleton babies. BMC Public Health, 7, 168.

    Article  PubMed Central  PubMed  Google Scholar 

  38. Boyd, N. R., Windsor, R. A., Perkins, L. L., & Lowe, J. B. (1998). Quality of measurement of smoking status by self-report and saliva cotinine among pregnant women. Maternal and Child Health Journal, 2(2), 77–83.

    Article  CAS  PubMed  Google Scholar 

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This study is a systematic review of previously published data and therefore does not require ethical approval.

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Correspondence to H. T. Wolf.

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Wolf, H.T., Owe, K.M., Juhl, M. et al. Leisure Time Physical Activity and the Risk of Pre-eclampsia: A Systematic Review. Matern Child Health J 18, 899–910 (2014). https://doi.org/10.1007/s10995-013-1316-8

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