Relation of various degrees of body mass index in patients with systemic hypertension to left ventricular mass, cardiac output, and peripheral resistance (The Hypertension Genetic Epidemiology Network Study)☆
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Population
The Hypertension Genetic Epidemiology Network study is part of the National Heart, Lung, and Blood Institute Family Blood Pressure Program, which assesses the genetic basis of hypertension in population-based samples,14 primarily relying on a sib-pair design that recruited hypertensive members of sibships. Hypertension was defined as receiving treatment or having systolic blood pressure ≥140 mm Hg and/or diastolic blood pressure ≥90 mm Hg. Criteria for eligibility were onset of high blood
LV mass and hemodynamics in normal-weight and overweight subjects
Hypertensive adults with mild to moderate or severe obesity were younger (53 and 50 years old, respectively) than normal-weight and overweight hypertensive subjects (55 and 56 years, both p <0.01), whereas no difference existed between the reference (53 years old) and any hypertensive (all p >0.7) group. The proportion of women was higher with mild to moderate and severe obesity (61% and 82%) than in normal-weight or overweight hypertensive or reference groups (56%, 54%, and 54%, respectively,
Discussion
In our study, overweight and obese hypertensive subjects had an absolute LV mass 15% to 41% higher than that in a reference normal group of normal-weight normotensive subjects, independent of gender and systolic blood pressure as important confounders. Of note, in overweight participants, FFM was 9% to 39% higher than in the reference groups, whereas an increase in fat mass ranged from 27% to 216%. Therefore, in hypertensive subjects, an increase in LV mass with overweight paralleled an
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This study was supported in part by Grant 5 R01 HL55673 and cooperative agreement Grants 5 U10 HL54471, HL 54472, HL54473, HL54496, HL54509, and HL 54515 from the National Heart, Lung, and Blood Institute, Bethesda; and Grant M10RR0047-34 (GCRC) from the National Institutes of Health, Bethesda, Maryland.