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The rule of 5 and the rule of 7 in lipid-lowering by statin drugs

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    2021, Journal of the American College of Cardiology
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    Statin users could be included if the statin dose or type had been changed within these 3 months. We calculated ‘atorvastatin’ equivalence to standardize the statin dose potency, as 1 atorvastatin equivalent = 5 mg of atorvastatin = rosuvastatin 1.25 mg = simvastatin 10 mg = lovastatin 20 mg = pravastatin 20 mg (13,14). Statin users were considered symptomatic or asymptomatic based on the presence, localization, and onset of muscle cramps, pain, and/or weakness, using the statin myalgia clinical index score (15).

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