Cell
Volume 116, Issue 2, 23 January 2004, Pages 281-297
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Review
MicroRNAs: Genomics, Biogenesis, Mechanism, and Function

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Abstract

MicroRNAs (miRNAs) are endogenous ∼22 nt RNAs that can play important regulatory roles in animals and plants by targeting mRNAs for cleavage or translational repression. Although they escaped notice until relatively recently, miRNAs comprise one of the more abundant classes of gene regulatory molecules in multicellular organisms and likely influence the output of many protein-coding genes.

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