Elsevier

The Lancet

Volume 386, Issue 9995, 22–28 August 2015, Page 717
The Lancet

Editorial
NICE antimicrobial stewardship: right drug, dose, and time?

https://doi.org/10.1016/S0140-6736(15)61522-7Get rights and content

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    Importantly, epidemiology of invasive infections is subject to change as a result of vaccination campaigns9 and the increasing number of patients at risk of acquiring health care-associated infections, including premature newborn babies, children with malignant disease, or after transplantation.10 Considering the detrimental effect of delays in antimicrobial treatment in bacterial sepsis,11 representative data for the contemporary burden of bacterial sepsis are key to guide national strategies for optimum antibiotic use.12 Sepsis in adults was redefined in 2016 as life-threatening organ dysfunction resulting from a dysregulated host response to infection.13

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