−592 and −1082 interleukin-10 polymorphisms in pulmonary tuberculosis with type 2 diabetes

Abstract

Objective

To determine the polymorphisms of Interleukin-10 (IL-10) (−592, −1082) in pulmonary tuberculosis (PTB) with and without type 2 diabetes (T2D).

Methods

We studied a Mexican mestizo population of 37 patients with TB in remission (TBr) and 40 with active pulmonary TB (PTB), 21 patients with TB + T2D, 47 blood donors accepted, and 13 healthy health-care workers with tuberculin skin test positive. Determination of IL-10 polymorphisms was performed by real-time Polymerase chain reaction.

Results

IL-10-592C/A presented in a greater proportion in healthy individuals than in patients with type 2 diabetes and TB in a not quite significant statistically manner. IL-10-1082A/A presented more frequently in the group of patients with both diseases, not being statistically significant in comparison with the group of healthy subjects.

Conclusions

This study describes two important new findings. First, it reveals that the IL-10 (−592 A/A and −592 C/C) polymorphisms were found in a greater proportion in a group of patients with T2D and TB than in healthy subjects. Second, the study provides evidence that the (−1082 G/G) polymorphism presented with greater frequency in healthy individuals than in patients with both of these diseases.