Trial DesignDesign and rationale of Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation: A global registry program on long-term oral antithrombotic treatment in patients with atrial fibrillation
Section snippets
Design
A registry is an organized data collection system that uses epidemiological study methods for collecting data to evaluate prespecified outcomes for a population defined by a particular disease, condition, or exposure, thus serving ≥1 predetermined scientific, clinical, or policy purposes.16 Within a registry, various epidemiological study designs can be applied, for example, cohort, case-control, or cross-sectional designs.
The GLORIA-AF registry program combines these different approaches
Discussion
The GLORIA-AF will be 1 of the largest AF-registry programs of its type, with an innovative design intended to minimize bias and be highly efficient. Its purpose is to collect long-term effectiveness and safety data on NOACs and VKA for stroke prevention in patients with nonvalvular AF and those receiving no antithrombotic therapy. The results will inform future treatment decisions and enhance understanding of public health aspects of this highly prevalent condition.
Observational studies are an
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Cited by (0)
Clinical trial registration: ClinicalTrials.gov nos. NCT01428765, NCT01468701, and NCT01671007.
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joint first authors, as chair and cochair, respectively.